ML 335

Tocris Bioscience, part of Bio-Techne | Catalog # 6887

Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator
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Key Product Details

Description

Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator

View all Two-P Potassium Channels Activators »

Product Description

ML 335 is a selective K2P2.1 (TREK-1; KCNK2) and K2P10.1 (TREK-2; KCNK10) activator (EC50 values of 14.3 μM and 5.2 μM, respectively); directly stimulates the C-type gate via the K2P modulator pocket. Does not activate K2P4.1 (TRAAK).

Product Specifications

Molecular Weight

373.25

Formula

C15H14Cl2N2O3S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[(2,4-Dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]benzamide

CAS Number

825658-06-8

PubChem ID

1243054

InChI Key

RDFIQTZRJRVFHK-UHFFFAOYSA-N

SMILES

CS(=O)(NC1=CC=C(C(NCC2=C(C=C(C=C2)Cl)Cl)=O)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.33 100
Ethanol 7.46 20

Preparing Stock Solutions for ML 335

The following data is based on the product molecular weight 373.25

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.40 mL 26.79 mL
5 mM 0.54 mL 2.68 mL 5.36 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for ML 335

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ML 335

For research use only

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