Quantikine Immunoassay Control Set 1203 Human Neuropilin-1

R&D Systems, part of Bio-Techne | Catalog # QC187B

For use with catalog number DNRP10
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Key Product Details

Species

Human

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: Neuropilin-1

Neuropilin-1 (NRP1) is a transmembrane glycoprotein that regulates axon guidance and angiogenesis. Distinct Neuropilin-1 domains mediate its binding to heparin, the heparin-binding forms of VEGF and PlGF (PlGF2), and Semaphorin 3. Neuropilin-1 can form homo- and hetero-oligomers with Neuropilin-2. Neuropilins show partially overlapping expression in neuronal and endothelial cells during development. They mediate axon repulsion on sensory and sympathetic neurons through binding to Class III Semaphorins, Plexin A3, and Plexin A4.  They also associate with VEGF R2 and function as coreceptors for VEGF. NRP1 is preferentially expressed in developing or remodeling arteries, epithelial cells, and carcinomas, while Neuropilin-2 is primarily found in veins and lymphatics. Neuroplin-1 is additionally expressed on dendritic cells where it mediates DC-induced T cell proliferation. NRP1 also plays a role in SARS-CoV-2 infection in humans, the virus responsible for COVID-19. The Spike protein of SARS-CoV-2 can bind to the b1 domain of Neuropilin-1 on the cell surface initiating viral entry into the host cell. Blocking the NRP1-Spike interaction reduces viral infectivity in vitro making it a potential therapeutic target.

Alternate Names

BDCA-4, CD304, Neuropilin1, NRP1

Entrez Gene IDs

8829 (Human); 18186 (Mouse); 246331 (Rat); 100286859 (Porcine)

Gene Symbol

NRP1

Additional Neuropilin-1 Products

Product Documents for Quantikine Immunoassay Control Set 1203 Human Neuropilin-1

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Quantikine Immunoassay Control Set 1203 Human Neuropilin-1

For research use only

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