Summary for Quantikine Immunoassay Control Set 1099 Human S100A8/S100A9
S100A8 (also MRP8 and calgranulin A) is a 10 kDa member of the S100 family, EF-hand superfamily of Ca-binding proteins. It is produced by neutrophils and monocytes, and forms Ca2+-dependent heterodimer/heterotetramer complexes (termed calprotectin) with S100A9. It functions both intracellularly and extracellularly, where it binds to RAGE and CD36. Human S100A8 is 93 amino acids (aa) in length. It contains two EF-hand motifs (aa 12 - 47 and 46 - 81) and one high-affinity Ca2+-binding site (aa 59 - 70). There may be one splice form that shows a 15 aa substitution for the C-terminal 14 amino acids. Although mouse S100A8 is cleaved by MMP-2 after Asn21, it is unclear if human S100A8 is susceptible. Full-length human S100A8 is 57% and 74% aa identical to mouse and canine S100A8, respectively.
Product Specifications for Quantikine Immunoassay Control Set 1099 Human S100A8/S100A9
Preparation & Storage
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Background: S100A8/S100A9 Heterodimer
S100 Calcium Binding Protein A8/S100 Calcium Binding Protein A9
Entrez Gene IDs
Calprotectin, S100A8/S100A9 Heterodimer
Citations for Quantikine Immunoassay Control Set 1099 Human S100A8/S100A9
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Product Documents for Quantikine Immunoassay Control Set 1099 Human S100A8/S100A9
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