Human IGF-I/IGF-1 Quantikine ELISA Kit Best Seller

Name: Human IGF-I/IGF-1 Quantikine ELISA Kit
Brand: R&D Systems
SKU: DG100B
Rating: 5 (16 reviews)

Catalog # DG100B | R&D Systems, Inc. a Bio-Techne Brand

(16)

Citations (138)

Product Datasheet / COA / SDS

Setting the standard in quality research reagents

Key Product Details

Assay Length:	4.5 hours
Sample Type & Volume Required Per Well:	Serum-free Cell Culture Supernates (13 uL), Serum (10 uL), EDTA Plasma (10 uL), Heparin Plasma (10 uL)
Sensitivity:	0.022 ng/mL
Assay Range:	0.063 - 4 ng/mL (Serum-free Cell Culture Supern, Serum, EDTA Plasma, Heparin Plasma)
Human IGF-I/IGF-1 Quantikine ELISA Kit Summary:	The Quantikine^® Human IGF-I/IGF-1 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human IGF-1 in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human IGF-1 and has antibodies raised againt the recombinant protein. Results obtained for naturally occurring human IGF-1 showed linear curves that were parallel to the standard curves obtained using the Quantikine^® kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IGF-1.

View Full Technical Details for Human IGF-I/IGF-1 Quantikine ELISA Kit

Technical Data
Citations (138) / Reviews (16)

Product Specifications for Human IGF-I/IGF-1 Quantikine ELISA Kit

Measurement	Quantitative ELISA
Detection Method	Colorimetric - 450nm (TMB)
Conjugate	HRP
Reactivity	Human
Specificity	Natural and recombinant human IGF-1.
Cross-reactivity	Cross-reactivity observed with 1 or more available related molecules. < 50% cross-species reactivity observed with species tested.
Interference	Interference observed with 1 or more available related molecules.

Precision

Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision

Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in twenty separate assays to assess inter-assay precision. Assays were performed by at least three technicians using two lots of components

Serum-free Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma

	Intra-Assay Precision			Inter-Assay Precision
Sample	1	2	3	1	2	3
n	20	20	20	20	20	20
Mean (ng/mL)	0.594	1.02	1.94	0.617	1.01	2.1
Standard Deviation	0.026	0.046	0.077	0.038	0.06	0.12
CV%	4.4	4.5	4	6.2	5.9	5.7

Recovery

The recovery of human IGF-1 spiked to three different levels throughout the range of the assay was evaluated. Samples were diluted prior to assay as described in the Sample Preparation section.

Sample Type	Average % Recovery	Range %
Cell Culture Media (n=4)	93	88-97

Linearity

To assess the linearity of the assay, samples containing and/or spiked with high concentrations of human IGF-1 were serially diluted with calibrator diluent to produce samples with values within the dynamic range of the assay. Samples were diluted prior to assay as described in the Sample Preparation section.

Scientific Data Examples for Human IGF-I/IGF-1 Quantikine ELISA Kit

	Human IGF-I/IGF-1 Standard Curve
	Human IGF-I ELISA Standard Curve

Preparation and Storage

Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: IGF-I/IGF-1

Insulin-like growth factor 1 (IGF-1, also known as somatomedin C) is a 7.6 kDa, 70 amino acid (aa) polypeptide with three internal disulfide bonds. The sequence of human IGF-1 is identical to that of bovine and porcine IGF-1, and is 70% identical to human IGF2. IGF-1 is a single-chain molecule with about 50% identity to the sequences of the A- and B-chains of human insulin.

IGF-1 is a growth hormone that plays a role in a variety of biological events. It is produced primarily by hepatocytes, serving an endocrine function. It is also produced by many other cells, where it may act in an autocrine or paracrine manner. It binds two tyrosine kinase receptors, the IGF-1 receptor (IGF1R) and the insulin receptor, to initiate downstream events like the AKT and PI3K signal transduction pathways. This triggers cell proliferation and protects cells from apoptosis. IGF-1 also interacts with seven IGF-binding proteins (IGFBP-1 through IGFBP7), influencing IGF-1 binding to IGF1R and increasing IGF-1 half-life to closely regulate IGF-1 signaling. For example, IGFBP-3 binds over 90% of the total IGF in serum in a complex of IGF, IGFBP, and an acid-labile subunit. This ternary complex greatly stabilizes IGF in the circulation, changing the half-life from minutes to hours. Proteases also facilitate IGF-1R binding by cleaving IGFBPs to modify their affinity for IGF or completely eliminate the IGFBP. The interactions of IGF, IGFBP, IGFBP proteases, and IGF receptors are referred to as the IGF axis.

The IGF axis affects many primary physiological and pathological processes, including development, growth, metabolic regulation, tumorigenesis, atherosclerosis, and angiogenesis. Its ability to inhibit apoptosis and stimulate cell growth and proliferation plays a significant role in prenatal development, growth to adulthood, and metabolic control. Serum levels of IGF-1 have been reported to increase from birth to puberty, followed by a slow decline through adulthood. IGF-1 also induces amino acid uptake, protein synthesis, and glucose utilization. In the brain, IGF-1 acts as a neurotrophic factor to promote neurogenesis and neuronal survival. Exercise increases levels of IGF-1 in blood serum, indicating it plays a role as a key mediator of exercise-induced neurogenesis.

Item	Value
Long Name	Insulin-like Growth Factor I/Insulin-like Growth Factor 1
Entrez Gene IDs	3479 (Human); 16000 (Mouse); 24482 (Rat)
Alternate Names	IBP1, IGF-1, IGF-I, IGF-IA, IGF-IB, IGF1, IGF1A, IGFI, MGF, Mechano growth factor, Somatomedin A, Somatomedin C, insulin-like growth factor 1, insulin-like growth factor 1 (somatomedin C), insulin-like growth factor I, insulin-like growth factor IA, insulin-like growth factor IB, somatomedin-C

Citations for Human IGF-I/IGF-1 Quantikine ELISA Kit (138)

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Citations are publications that use Bio-Techne products. Selected citations for Human IGF-I/IGF-1 Quantikine ELISA Kit include:

Species: Human
Sample Types: Cell Culture Supernates

Asparuhova et al. (2023-05-04), Local Concentrations of TGF-?1 and IGF-1 Appear Determinant in Regulating Bone Regeneration in Human Postextraction Tooth Sockets International journal of molecular sciences
PMID: 37175951
Species: Human
Sample Types: Plasma

J Araújo Fiu et al. (2022-10-05), The role of environmental enteric dysfunction in the pathogenesis of Schistosoma mansoni-associated morbidity in school-aged children PloS Neglected Tropical Diseases, 2022-116(10):e0010837.
PMID: 36197916
Species: Human
Sample Types: Serum

MLA Robinson-A et al. (2022-08-12), BDNF, proBDNF and IGF-1 serum levels in naï¿½ve and medicated subjects with autism Scientific Reports, 2022-012(1):13768.
PMID: 35962006
Species: Bovine
Sample Types: Plasma

JM Baldrighi et al. (2022-07-15), Temporal evaluation of follicular dynamics and endocrine patterns of Holstein (Bos taurus), Gir (Bos indicus), and Murrah (Bubalus bubalis) heifers kept under the same nutritional, management and environmental conditions Oncogene, 2022-0190(0):8-14.
PMID: 35863098
Species: Bovine
Sample Types: Serum

RS Carvalho et al. (2022-06-18), Influence of body condition score and its change after parturition on pregnancy rates to fixed-timed artificial insemination in Bos indicus beef cows Oncogene, 2022-0243(0):107028.
PMID: 35759852
Species: Human
Sample Types: Plasma

CJ Brakenridg et al. (2022-05-10), Sitting less and moving more for improved metabolic and brain health in type 2 diabetes: 'OPTIMISE your health' trial protocol BMC Public Health, 2022-022(1):929.
PMID: 35538430
Species: Mouse, Rat
Sample Types: Serum

H Nishi et al. (2022-05-02), Essential Amino Acid Intake Is Required for Sustaining Serum Insulin-like Growth Factor-I Levels but Is Not Necessarily Needed for Body Growth Cells, 2022-011(9).
PMID: 35563827
Species: Human
Sample Types: Tissue Homogenates

C Zhong et al. (2022-02-18), HOXA-AS2 contributes to regulatory T cell proliferation and immune tolerance in glioma through the miR-302a/KDM2A/JAG1 axis Cell Death Disease, 2022-02-18;13(2):160.
PMID: 35181676
Species: Human
Sample Types: Serum

JA Goldsmith et al. (2022-02-10), Visceral Adiposity, Inflammation, and Testosterone Predict Skeletal Muscle Mitochondrial Mass and Activity in Chronic Spinal Cord Injury Frontiers in Physiology, 2022-013(0):809845.
PMID: 35222077
Species: Human
Sample Types: Serum

F D'Addio et al. (2022-02-03), The IGFBP3/TMEM219 pathway regulates beta cell homeostasis Nature Communications, 2022-013(1):684.
PMID: 35115561
Species: Human
Sample Types: Serum

SW Jhan et al. (2022-01-18), Comparison of Extracorporeal Shockwave Therapy with Non-Steroid Anti-Inflammatory Drugs and Intra-Articular Hyaluronic Acid Injection for Early Osteoarthritis of the Knees Biomedicines, 2022-010(2).
PMID: 35203417
Species: Human
Sample Types: Plasma

AL Huber et al. (2021-12-15), Effects of Intravitreal Aflibercept on the Systemic Insulin-like Growth Factor-I and Vascular Endothelial Growth Factor-A in Patients with Diabetic Retinopathy and Age-Related Macular Degeneration Journal of Ophthalmology, 2021-12021(0):7058505.
PMID: 34956670
Species: Human
Sample Types: Cell Culture Supernates

F Kang et al. (2021-12-11), Controlled growth factor delivery system with osteogenic-angiogenic coupling effect for bone regeneration Journal of Orthopaedic Translation, 2021-131(0):110-125.
PMID: 34976731
Species: Human
Sample Types: Plasma

JM Dreyfuss et al. (2021-11-29), High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control Nature Communications, 2021-112(1):6951.
PMID: 34845204
Species: Human
Sample Types: Plasma

L Bian et al. (2021-08-05), Copeptin and insulin-like growth factor-1 predict long-term outcomes after aneurysmal subarachnoid hemorrhage: A large prospective cohort study Clinical neurology and neurosurgery, 2021-0209(0):106863.
PMID: 34474332
Species: Human
Sample Types: Serum

M Sylvawani et al. (2021-06-11), Comparison of insulin-like growth factor-1 and sclerostin levels between premenopausal women with and without diabetes mellitus Journal of Taibah University Medical Sciences, 2021-016(5):719-723.
PMID: 34690653
Species: Human
Sample Types: Plasma

Y Tsuchiya et al. (2021-05-29), Myokine secretion following moderate-intensity endurance exercise under different environmental temperatures Cytokine, 2021-0144(0):155553.
PMID: 34062449
Species: Human
Sample Types: Cell Culture Supernates

F Fan et al. (2021-05-18), JunB is a key regulator of multiple myeloma bone marrow angiogenesis Leukemia, 2021-00(0).
PMID: 34007044
Species: Human
Sample Types: Plasma

L Berben et al. (2021-05-02), Blood Immunosenescence Signatures Reflecting Age, Frailty and Tumor Immune Infiltrate in Patients with Early Luminal Breast Cancer Cancers, 2021-013(9).
PMID: 34063210
Species: Human
Sample Types: Serum

K Miyamoto et al. (2021-04-28), A Metabolomic Profile Predictive of New Osteoporosis or Sarcopenia Development Metabolites, 2021-011(5).
PMID: 33924750
Species: Human
Sample Types: Cell Culture Supernates

L Luo et al. (2021-03-17), Exploring a Chemotactic Role for EVs from Progenitor Cell Populations of Human Exfoliated Deciduous Teeth for Promoting Migration of Naï¿½ve BMSCs in Bone Repair Process Stem Cells International, 2021-02021(0):6681771.
PMID: 33815511
Species: Human
Sample Types: Plasma

N Casagrande et al. (2021-03-16), In Ovarian Cancer Multicellular Spheroids, Platelet Releasate Promotes Growth, Expansion of ALDH+ and CD133+ Cancer Stem Cells, and Protection against the Cytotoxic Effects of Cisplatin, Carboplatin and Paclitaxel International Journal of Molecular Sciences, 2021-022(6).
PMID: 33809553
Species: Mouse
Sample Types: Serum

DW Dodington et al. (2021-03-08), JAK2-IGF1 axis in osteoclasts regulates postnatal growth in mice JCI Insight, 2021-06(5).
PMID: 33682794
Species: Human
Sample Types: Plasma

B Cakir et al. (2020-10-02), IGF1, serum glucose, and retinopathy of prematurity in extremely preterm infants JCI Insight, 2020-15(19).
PMID: 33004691
Species: Human
Sample Types: Serum

KM Terlikowsk et al. (2020-09-25), Clinical value of selected markers of angiogenesis, inflammation, insulin resistance and obesity in type 1 endometrial cancer BMC Cancer, 2020-020(1):921.
PMID: 32977765
Species: Human
Sample Types: Serum

F Buckinx et al. (2020-07-25), High intensity interval training combined with L-citrulline supplementation: Effects on physical performance in healthy older adults Exp. Gerontol., 2020-00(0):111036.
PMID: 32721549
Species: Human
Sample Types: Protein

Q Min et al. (2020-06-20), Controlled Delivery of Insulin-like Growth Factor-1 from Bioactive Glass-Incorporated Alginate-Poloxamer/Silk Fibroin Hydrogels Pharmaceutics, 2020-012(6).
PMID: 32575684
Species: Human
Sample Types: Serum

P Fahlbusch et al. (2020-06-10), Physiological Disturbance in Fatty Liver Energy Metabolism Converges on IGFBP2 Abundance and Regulation in Mice and Men Int J Mol Sci, 2020-021(11).
PMID: 32532003
Species: Human

L Van Dyck et al. (2020-05-24), Towards a fasting-mimicking diet for critically ill patients: the pilot randomized crossover ICU-FM-1 study Crit Care, 2020-024(1):249.
PMID: 32448392
Species: Human
Sample Types: Serum

OA Levada et al. (2020-05-08), Serum insulin-like growth factor-1 as a potential marker for MDD diagnosis, its clinical characteristics, and treatment efficacy validation: data from an open-label vortioxetine study BMC Psychiatry, 2020-020(1):208.
PMID: 32384884
Species: Bovine
Sample Types: Serum

OB Pascottini et al. (2020-03-23), Effect of anti-inflammatory treatment on systemic inflammation, immune function, and endometrial health in postpartum dairy cows Sci Rep, 2020-010(1):5236.
PMID: 32251312
Species: Human
Sample Types: Plasma

Z Zeng et al. (2020-03-18), PM2.5-bound PAHs exposure linked with low plasma insulin-like growth factor 1 levels and reduced child height Environ Int, 2020-0138(0):105660.
PMID: 32199227
Species: Human
Sample Types: Serum

G Nagel et al. (2020-01-20), Association of Insulin-like Growth Factor 1 Concentrations with Risk for and Prognosis of Amyotrophic Lateral Sclerosis - Results from the ALS Registry Swabia Sci Rep, 2020-010(1):736.
PMID: 31959864
Species: Human
Sample Types: Cell Culture Supernates

S Nakai et al. (2019-11-01), Establishment of a novel human CIC-DUX4 sarcoma cell line, Kitra-SRS, with autocrine IGF-1R activation and metastatic potential to the lungs Sci Rep, 2019-19(1):15812.
PMID: 31676869
Species: Human
Sample Types: Serum

T Nakajima et al. (2019-10-01), Growth Differentiation Factor-15 (GDF-15) is a Biomarker of Muscle Wasting and Renal Dysfunction in Preoperative Cardiovascular Surgery Patients J Clin Med, 2019-18(10).
PMID: 31581569
Species: Human
Sample Types: Serum

N Kiriakopou et al. (2019-07-27), Investigating Stress Response during Vaginal Delivery and Elective Cesarean Section through Assessment of Levels of Cortisol, Interleukin 6 (IL-6), Growth Hormone (GH) and Insulin-Like Growth Factor 1 (IGF-1) J Clin Med, 2019-08(8).
PMID: 31357604
Species: Human
Sample Types: Cell Culture Supernates

X Zheng et al. (2019-07-20), An Autocrine IL-6/IGF-1R Loop Mediates EMT and Promotes Tumor Growth in Non-small Cell Lung Cancer Int. J. Biol. Sci., 2019-015(9):1882-1891.
PMID: 31523190
Species: Human
Sample Types: Plasma

C Bourdon et al. (2019-06-27), Metabolomics in plasma of Malawian children 7?years after surviving severe acute malnutrition: "ChroSAM" a cohort study EBioMedicine, 2019-00(0).
PMID: 31255658
Species: Human
Sample Types: Serum

KP Dzik et al. (2019-06-02), Vitamin D Deficiency Is Associated with Muscle Atrophy and Reduced Mitochondrial Function in Patients with Chronic Low Back Pain Oxid Med Cell Longev, 2019-02019(0):6835341.
PMID: 31281588
Species: Human
Sample Types: Cell Culture Supernates

S Morscheid et al. (2019-05-27), Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-? and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells Int J Mol Sci, 2019-020(10).
PMID: 31137788
Species: Human
Sample Types: Plasma

LF Esemu et al. (2019-05-01), Impact of HIV-1 infection on the IGF-1 axis and angiogenic factors in pregnant Cameroonian women receiving antiretroviral therapy PLoS ONE, 2019-014(5):e0215825.
PMID: 31042729
Species: Human
Sample Types: Cell Culture Supernates

MJ Sebastião et al. (2019-03-07), Human cardiac progenitor cell activation and regeneration mechanisms: exploring a novel myocardial ischemia/reperfusion in vitro model Stem Cell Res Ther, 2019-010(1):77.
PMID: 30845956
Species: Human
Sample Types: Plasma

A Malin Igra et al. (2019-03-01), Early-Life Cadmium Exposure and Bone-Related Biomarkers: A Longitudinal Study in Children Environ. Health Perspect., 2019-0127(3):37003.
PMID: 30848671
Species: Human
Sample Types: Plasma

RH Bartels et al. (2019-02-19), Hypoallergenic and anti-inflammatory feeds in children with complicated severe acute malnutrition: an open randomised controlled 3-arm intervention trial in Malawi Sci Rep, 2019-09(1):2304.
PMID: 30783173
Species: Human
Sample Types: Serum

V Andreu-Fer et al. (2019-02-07), Serum concentrations of IGF-I/IGF-II as biomarkers of alcohol damage during foetal development and diagnostic markers of Foetal Alcohol Syndrome Sci Rep, 2019-09(1):1562.
PMID: 30733584
Species: Human
Sample Types: Cell Culture Supernates

ZJ Liang et al. (2019-01-24), Ginsenoside Rg1 Accelerates Paracrine Activity and Adipogenic Differentiation of Human Breast Adipose-Derived Stem Cells in a Dose-Dependent Manner In Vitro Cell Transplant, 2019-00(0):9636897198256.
PMID: 30675799
Species: Human
Sample Types: Cell Culture Supernates

V Jeyakumar et al. (2019-01-14), Redifferentiation of Articular Chondrocytes by Hyperacute Serum and Platelet Rich Plasma in Collagen Type I Hydrogels Int J Mol Sci, 2019-020(2).
PMID: 30646566
Species: Human
Sample Types: Cell Culture Supernates

M Suto et al. (2019-01-01), A Potato Peel Extract Stimulates Type I Collagen Synthesis via Akt and ERK Signaling in Normal Human Dermal Fibroblasts Biol. Pharm. Bull., 2019-042(9):1510-1516.
PMID: 31474711
Species: Human
Sample Types: Plasma

M Krause et al. (2018-12-05), The effects of a combined bodyweight-based and elastic bands resistance training, with or without protein supplementation, on muscle mass, signaling and heat shock response in healthy older people Exp. Gerontol., 2018-1115(0):104-113.
PMID: 30529477
Species: Human
Sample Types: Plasma

S Pauly et al. (2018-11-30), The effect of autologous platelet rich plasma on tenocytes of the human rotator cuff BMC Musculoskelet Disord, 2018-119(1):422.
PMID: 30497435
Species: Human
Sample Types: Serum

J Jaworska et al. (2018-11-28), A 2-Week Specific Volleyball Training Supported by the Whole Body Cryostimulation Protocol Induced an Increase of Growth Factors and Counteracted Deterioration of Physical Performance Front Physiol, 2018-19(0):1711.
PMID: 30555349
Species: Human
Sample Types: Cell Culture Supernates

F Agostini et al. (2018-09-06), 1H-NMR and MALDI-TOF MS as metabolomic quality control tests to classify platelet derived medium additives for GMP compliant cell expansion procedures PLoS ONE, 2018-013(9):e0203048.
PMID: 30188924
Species: Human
Sample Types: Cell Culture Supernates

DH Bak et al. (2018-08-27), Human umbilical cord blood mesenchymal stem cells engineered to overexpress growth factors accelerate outcomes in hair growth Korean J. Physiol. Pharmacol., 2018-022(5):555-566.
PMID: 30181702
Species: Human
Sample Types: Cell Cultue Supernates

W Zhou et al. (2018-08-05), Matrine induces senescence of human glioblastoma cells through suppression of the IGF1/PI3K/AKT/p27 signaling pathway Cancer Med, 2018-00(0).
PMID: 30079478
Species: Human
Sample Types: Serum

Y Huber et al. (2018-07-31), Validation of insulin-like growth factor-1 as a prognostic parameter in patients with hepatocellular carcinoma in a European cohort BMC Cancer, 2018-018(1):774.
PMID: 30064393
Species: Human
Sample Types: Serum

V Racca et al. (2018-07-17), Differences in biochemical markers between Heart-transplanted and Left Ventricular Assist Device implanted patients, during cardiac rehabilitation Sci Rep, 2018-08(1):10816.
PMID: 30018333
Species: Rabbit
Sample Types: Complex Sample Type

MY Bai et al. (2018-07-13), Relationships of Age and Sex with Cytokine Content and Distribution in Human Platelet Fibrin Gels Sci Rep, 2018-08(1):10642.
PMID: 30006555
Species: Human
Sample Types: Cell Lysates

A Baigger et al. (2018-06-12), Characterization of induced pluripotent stem cell-derived megakaryocyte lysates for potential regenerative applications J. Cell. Mol. Med., 2018-00(0).
PMID: 29893509
Species: Bovine
Sample Types: Serum

ZK Smith et al. (2018-05-04), Evaluation of Coated Steroidal Implants Containing Trenbolone Acetate and Estradiol-17? on Live Performance, Carcass Traits, and Sera Metabolites in Finishing Steers J. Anim. Sci., 2018-00(0).
PMID: 29534183
Species: Human
Sample Types: Cell Culture Supernates

C Saury et al. (2018-05-02), Human serum and platelet lysate are appropriate xeno-free alternatives for clinical-grade production of human MuStem cell batches Stem Cell Res Ther, 2018-09(1):128.
PMID: 29720259
Species: Human
Sample Types: Plasma

T Astuti et al. (2018-05-01), The levels of pro-fibrotic cytokines in pulmonary tuberculosis with minimal and extensive lesions Lung India, 2018-035(3):204-208.
PMID: 29697076
Species: Human
Sample Types: Serum

DB Brimhall et al. (2018-04-24), Relative Bioavailability of a Single 4-mg Dose of Somatropin Administered by Subcutaneous Injection or by Needle-free Device and Coadministered With the Growth Hormone Inhibitor Octreotide Acetate in Healthy Adult Subjects Clin Ther, 2018-00(0).
PMID: 29699852
Species: Mouse
Sample Types: Serum

SW Carlson et al. (2018-04-17), Central Infusion of IGF-1 Increases Hippocampal Neurogenesis and Improves Neurobehavioral Function following Traumatic Brain Injury J. Neurotrauma, 2018-00(0).
PMID: 29455576
Species: Bovine
Sample Types: Serum

AL Belli et al. (2018-04-11), Effects of treatment of preweaning dairy calves with recombinant bovine somatotropin on immune responses and somatotropic axis J. Dairy Sci., 2018-00(0).
PMID: 29655555
Species: Human
Sample Types: Serum

L Woost et al. (2018-03-09), Physical Exercise and Spatial Training: A Longitudinal Study of Effects on Cognition, Growth Factors, and Hippocampal Plasticity Sci Rep, 2018-08(1):4239.
PMID: 29523857
Species: Bovine
Sample Types: Plasma

MB Piccolo et al. (2018-03-06), Pre-weaning injections of bovine somatotropin enhanced reproductive performance of Bos indicus-influenced replacement beef heifers J. Anim. Sci., 2018-00(0).
PMID: 29385608
Species: Human
Sample Types: Serum

AK Sawicka et al. (2018-02-23), l-Carnitine Supplementation in Older Women. A Pilot Study on Aging Skeletal Muscle Mass and Function Nutrients, 2018-010(2).
PMID: 29473908
Species: Human
Sample Types: Tears

R Patel et al. (2018-02-06), Shifting the IGF-axis: An age-related decline in human tear IGF-1 correlates with clinical signs of dry eye Growth Horm. IGF Res., 2018-00(0).
PMID: 29452886
Species: Rat
Sample Types: Tissue Homogenates

KD Beharry et al. (2018-01-01), Impact of Chronic Neonatal Intermittent Hypoxia on Severity of Retinal Damage in a Rat Model of Oxygen-Induced Retinopathy J Nat Sci, 2018-04(3).
PMID: 29552637
Species: Human
Sample Types: Serum

M Picillo et al. (2017-10-24), Serum IGF-1 is associated with cognitive functions in early, drug-naï¿½ve Parkinson's disease PLoS ONE, 2017-112(10):e0186508.
PMID: 29065116
Species: Human
Sample Types: Plasma

G Zhao et al. (2017-09-28), Effect of Physical Activity on Cognitive Development: Protocol for a 15-Year Longitudinal Follow-Up Study Biomed Res Int, 2017-02017(0):8568459.
PMID: 29094050
Species: Human
Sample Types: Cell Culture Supernates

K Nagaishi et al. (2017-08-16), Umbilical cord extracts improve diabetic abnormalities in bone marrow-derived mesenchymal stem cells and increase their therapeutic effects on diabetic nephropathy Sci Rep, 2017-07(1):8484.
PMID: 28814814
Species: Human
Sample Types: Plasma

G Annibalini et al. (2017-06-21), Concurrent Aerobic and Resistance Training Has Anti-Inflammatory Effects and Increases Both Plasma and Leukocyte Levels of IGF-1 in Late Middle-Aged Type 2 Diabetic Patients Oxid Med Cell Longev, 2017-02017(0):3937842.
PMID: 28713486
Species: Human
Sample Types: Serum

Y Miura et al. (2017-05-11), Five-weekly S-1 plus cisplatin therapy combined with trastuzumab therapy in HER2-positive gastric cancer: a phase II trial and biomarker study (WJOG7212G) Gastric Cancer, 2017-00(0).
PMID: 28497176
Species: Human
Sample Types: Cell Culture Supernates

J Frisch et al. (2017-05-03), Peripheral blood aspirates overexpressing IGF-I via rAAV gene transfer undergo enhanced chondrogenic differentiation processes J. Cell. Mol. Med., 2017-00(0).
PMID: 28467017
Species: Human
Sample Types: Cell Lysates

M Bernardi et al. (2017-05-01), The production method affects the efficacy of platelet derivatives to expand mesenchymal stromal cells in vitro J Transl Med, 2017-015(1):90.
PMID: 28460641
Species: Human
Sample Types: Tissue Homogenates

M Yoshikawa et al. (2017-05-01), Evaluation of autologous skeletal muscle-derived factors for regenerative medicine applications Bone Joint Res, 2017-06(5):277-283.
PMID: 28473335
Species: Ovine
Sample Types: Serum

W Xu et al. (2017-04-02), Temporal changes in liver tissue metabolome of lambs fed low-quality roughage Anim. Sci. J., 2017-00(0).
PMID: 28370901
Species: Human
Sample Types: Cell Culture Supernates

W Katagiri et al. (2017-03-25), Angiogenesis in newly regenerated bone by secretomes of human mesenchymal stem cells Maxillofac Plast Reconstr Surg, 2017-039(1):8.
PMID: 28405581
Species: Human
Sample Types: Serum

JR Gee et al. (2017-03-21), A phase II randomized, double-blind, presurgical trial of Polyphenon E in bladder cancer patients to evaluate pharmacodynamics and bladder tissue biomarkers Cancer Prev Res (Phila), 2017-00(0).
PMID: 28325826
Species: Human
Sample Types: Cell Culture Supernates

Z Wang et al. (2017-03-02), Metformin inhibits the proliferation of benign prostatic epithelial cells PLoS ONE, 2017-012(3):e0173335.
PMID: 28253329
Species: Human
Sample Types: Cell Culture Supernates

Y Tanaka et al. (2017-02-15), Hypoxic preconditioning of human cardiosphere-derived cell sheets enhances cellular functions via activation of the PI3K/Akt/mTOR/HIF-1? pathway Am J Transl Res, 2017-09(2):664-673.
PMID: 28337294
Species: Human
Sample Types: Plasma

P Gentile et al. (2017-02-14), Evaluation of Not-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems Int J Mol Sci, 2017-018(2).
PMID: 28216604
Species: Human
Sample Types: Serum

Francesca Pirini (2017-02-01), Prenatal exposure to tobacco smoke leads to increased mitochondrial DNA content in umbilical cord serum associated to reduced gestational age Int J Environ Health Res, 2017-027(1):52-67.
PMID: 28002977
Species: Human
Sample Types: Serum

JP Dias et al. (2017-01-19), Effects of transdermal testosterone gel or an aromatase inhibitor on serum concentration and pulsatility of growth hormone in older men with age-related low testosterone Metab. Clin. Exp., 2017-069(0):143-147.
PMID: 28285644
Species: Human
Sample Types: Plasma

A Olszanecka et al. (2017-01-12), Relationships of insulin-like growth factor-1, its binding proteins, and cardiometabolic risk in hypertensive perimenopausal women Metab. Clin. Exp., 2017-069(0):96-106.
PMID: 28285656
Species: Human
Sample Types: Cell Culture Supernates

(2016-12-19), Impact of Hyperglycemia and Low Oxygen Tension on Adipose-Derived Stem Cells Compared with Dermal Fibroblasts and Keratinocytes: Importance for Wound Healing in Type 2 Diabetes PLoS ONE, 2016-111(12):e0168058.
PMID: 27992567
Species: Human
Sample Types: Serum

(2016-12-15), Genetic variation in IGF1 predicts renal cell carcinoma susceptibility and prognosis in Chinese population Sci Rep, 2016-16(0):39014.
PMID: 27976731
Species: Human
Sample Types: Plasma

Martine M Perrigue (2016-12-05), Randomized Trial Testing the Effects of Eating Frequency on Two Hormonal Biomarkers of Metabolism and Energy Balance Nutr Cancer, 2016-10(0):1-8.
PMID: 27918854
Species: Human
Sample Types: Cell Culture Supernates

Anne Fischer-Ni (2016-11-22), Overcoming the bottleneck of platelet lysate supply in large-scale clinical expansion of adipose-derived stem cells: A comparison of fresh versus three types of platelet lysates from outdated buffy coat-derived platelet concentrates Cytotherapy, 2016-10(0).
PMID: 27887865
Species: Human
Sample Types: Serum
Applications: ELISA Capture

Matthew P Rowan et al. (2016-10-04), Elevations in growth hormone and glucagon-like peptide-2 levels on admission are associated with increased mortality in trauma patients. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2016-10(0):1757-7241.
PMID: 27716276
Species: Human
Sample Types: Cell Culture Supernates

(2016-09-26), The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells Nat Commun, 2016-07(0):12961.
PMID: 27666821
Species: Human
Sample Types: Plasma

M Szczuko (2016-09-23), High glycemic index diet in PCOS patients. The analysis of IGF I and TNF-? pathways in metabolic disorders Med. Hypotheses, 2016-096(0):42-47.
PMID: 27959274
Species: Human
Sample Types: Plasma

Gorka Orive (2016-09-22), Biological effects of plasma rich in growth factors (PRGF) on human endometrial fibroblasts Eur. J. Obstet. Gynecol. Reprod. Biol., 2016-0206(0):125-130.
PMID: 27693932
Species: Human
Sample Types: Serum

Howard H Bailey (2016-09-20), Phase IIa, randomized placebo-controlled trial of single high dose cholecalciferol (vitamin D3) and daily Genistein (G-2535) versus double placebo in men with early stage prostate cancer undergoing prostatectomy Am J Clin Exp Urol, 2016-04(2):17-27.
PMID: 27766277
Species: Human
Sample Types: Plasma

O Bottasso (2016-09-12), An adverse immune-endocrine profile in patients with tuberculosis and type 2 diabetes Tuberculosis (Edinb), 2016-0101(0):95-101.
PMID: 27865406
Species: Human
Sample Types: Cell Culture Supernates

(2016-09-09), Adipose-derived mesenchymal stem cells from patients with atherosclerotic renovascular disease have increased DNA damage and reduced angiogenesis that can be modified by hypoxia Stem Cell Res Ther, 2016-07(1):128.
PMID: 27612459
Species: Human
Sample Types: CSF

Matthew N Svalina (2016-06-03), IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma Sci Rep, 2016-06(0):27012.
PMID: 27255663
Species: Human
Sample Types: Serum

Zeng Wang (2016-05-26), A preliminary study of pamidronic acid downregulation of angiogenic factors IGF-1/PECAM-1 expression in circulating level in bone metastatic breast cancer patients Onco Targets Ther, 2016-09(0):3147-52.
PMID: 27307756
Species: Human
Sample Types: Cell Culture Supernates

D Dauwe et al. (2016-04-18), Neovascularization Potential of Blood Outgrowth Endothelial Cells From Patients With Stable Ischemic Heart Failure Is Preserved J Am Heart Assoc, 2016-05(4).
PMID: 27091182
Species: Human
Sample Types: Cell Culture Supernates

Magali Cucchiarin (2015-07-22), Chondrogenic Differentiation Processes in Human Bone Marrow Aspirates upon rAAV-Mediated Gene Transfer and Overexpression of the Insulin-Like Growth Factor I Tissue Eng Part A, 2015-021(17):2460-71.
PMID: 26123891
Species: Human
Sample Types: Serum

Kim H et al. (2015-02-06), Effects of exercise and milk fat globule membrane (MFGM) supplementation on body composition, physical function, and hematological parameters in community-dwelling frail Japanese women: a randomized double blind, placebo-controlled, follow-up trial. PLoS ONE, 2015-010(2):e0116256.
PMID: 25659147
Species: Human
Sample Types: Cell Culture Supernates

Tworkoski K et al. (2014-12-17), LMP1 promotes expression of insulin-like growth factor 1 (IGF1) to selectively activate IGF1 receptor and drive cell proliferation. J Virol, 2014-189(5):2590-602.
PMID: 25520502
Species: Equine
Sample Types: Synovial Fluid

Ortved K et al. (2014-10-14), Implantation of rAAV5-IGF-I transduced autologous chondrocytes improves cartilage repair in full-thickness defects in the equine model. Mol Ther, 2014-123(2):363-73.
PMID: 25311491
Species: Human
Sample Types: Plasma

Lee O et al. (2014-07-15), A randomized phase II presurgical trial of transdermal 4-hydroxytamoxifen gel versus oral tamoxifen in women with ductal carcinoma in situ of the breast. Clin Cancer Res, 2014-020(14):3672-82.
PMID: 25028506
Species: Human
Sample Types: Cell Culture Supernates

Cucchiarini M et al. (2014-07-03), Overexpression of human IGF-I via direct rAAV-mediated gene transfer improves the early repair of articular cartilage defects in vivo. Gene Ther, 2014-021(9):811-9.
PMID: 24989812
Species: Human
Sample Types: Plasma

Ahmed S et al. (2013-11-26), Arsenic exposure affects plasma insulin-like growth factor 1 (IGF-1) in children in rural Bangladesh. PLoS ONE, 2013-18(11):e81530.
PMID: 24303053
Species: Human
Sample Types: Cell Culture Supernates

Kinzebach S et al. (2013-10-30), Functional and differential proteomic analyses to identify platelet derived factors affecting ex vivo expansion of mesenchymal stromal cells. BMC Cell Biol, 2013-114(0):48.
PMID: 24168020
Species: Human
Sample Types: Serum

Braicu E et al. (2013-02-14), Role of serum concentration of VEGFR1 and TIMP2 on clinical outcome in primary cervical cancer: results of a companion protocol of the randomized, NOGGO-AGO phase III adjuvant trial of simultaneous cisplatin-based radiochemotherapy vs. carboplatin and paclitaxel containing sequential radiotherapy. Cytokine, 2013-061(3):755-8.
PMID: 23415672
Species: Human
Sample Types: Tissue Homogenates

Ho I et al. (2013-01-01), Human bone marrow-derived mesenchymal stem cells suppress human glioma growth through inhibition of angiogenesis. Stem Cells, 2013-031(1):146-55.
PMID: 23034897
Species: Human
Sample Types: Cell Culture Supernates

Weimer A et al. (2012-05-09), Benefits of recombinant adeno-associated virus (rAAV)-mediated insulinlike growth factor I (IGF-I) overexpression for the long-term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis. Mol. Med., 2012-018(1):346-58.
PMID: 22160392
Species: Human
Sample Types: Plasma

Higgins MF et al. (2012-02-17), Maternal and fetal placental growth hormone and IGF axis in type 1 diabetic pregnancy. PLoS ONE, 2012-07(2):e29164.
PMID: 22363400
Species: Human
Sample Types: Plasma

McGuire TR et al. (2011-09-08), Inflammation associated with obesity: relationship with blood and bone marrow endothelial cells. Obesity (Silver Spring), 2011-019(11):2130-6.
PMID: 21901025
Species: Human
Sample Types: Serum

Landt S et al. (2011-08-01), Prognostic significance of angiogenic factors in uterine cervical cancer. Anticancer Res., 2011-031(8):2589-95.
PMID: 21778309
Species: Human
Sample Types: Serum

Morgan K et al. (2011-06-02), The stature of boys is inversely correlated to the levels of their sertoli cell hormones: do the testes restrain the maturation of boys? PLoS ONE, 2011-06(6):e20533.
PMID: 21655101
Species: Human
Sample Types: Cell Lysates

Rauch C et al. (2011-01-01), Alternatives to the use of fetal bovine serum: human platelet lysates as a serum substitute in cell culture media. ALTEX, 2011-028(4):305-16.
PMID: 22130485
Species: Human
Sample Types: Serum

Volkova E et al. (2010-11-16), Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer. Br. J. Cancer, 2010-1104(1):51-9.
PMID: 21081932
Species: Human
Sample Types: Cell Culture Supernates

Li TS et al. (2010-07-29), Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair. Cardiovasc. Res., 2010-089(1):157-65.
PMID: 20675298
Species: Human
Sample Types: Plasma

Sesso R et al. (2009-11-05), Abnormalities in metalloproteinase pathways and IGF-I axis: a link between birth weight, hypertension, and vascular damage in childhood. Am. J. Hypertens., 2009-123(1):6-11.
PMID: 19893495
Species: Human
Sample Types: CSF

Mastroeni R et al. (2009-07-01), Insulin-like growth factor-1 and neurotrophin-3 gene therapy prevents motor decline in an X-linked adrenoleukodystrophy mouse model. Ann. Neurol., 2009-066(1):117-22.
PMID: 19670442
Species: Human
Sample Types: Cell Culture Supernates

Eckstein N et al. (2009-03-24), Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells. Cancer Res., 2009-069(7):2996-3003.
PMID: 19318572
Species: Human
Sample Types: Cell Culture Supernates

Sorrentino A et al. (2008-05-27), Isolation and characterization of CD146+ multipotent mesenchymal stromal cells. Exp. Hematol., 2008-036(8):1035-46.
PMID: 18504067
Species: Human
Sample Types: Cell Culture Supernates

Siddappa R et al. (2008-05-19), cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo. Proc. Natl. Acad. Sci. U.S.A., 2008-0105(20):7281-6.
PMID: 18490653
Species: Human
Sample Types: Serum

Ashare A et al. (2008-04-24), Insulin-like growth factor-1 improves survival in sepsis via enhanced hepatic bacterial clearance. Am. J. Respir. Crit. Care Med., 2008-0178(2):149-57.
PMID: 18436791
Species: Human
Sample Types: BALF

Pulichino AM et al. (2008-04-10), Identification of transforming growth factor beta1-driven genetic programs of acute lung fibrosis. Am. J. Respir. Cell Mol. Biol., 2008-039(3):324-36.
PMID: 18403781
Species: Canine, Human
Sample Types: Plasma, Recombinant Protein

Lanz TA et al. (2007-11-12), Peripheral elevation of IGF-1 fails to alter Abeta clearance in multiple in vivo models. Biochem. Pharmacol., 2007-175(5):1093-103.
PMID: 18076866
Species: Human
Sample Types: Follicular Fluid

Asimakopoulos B et al. (2007-11-05), The levels of steroid hormones and cytokines in individual follicles are not associated with the fertilization outcome after intracytoplasmic sperm injection. Fertil. Steril., 2007-190(1):60-4.
PMID: 17980366
Species: Human
Sample Types: Plasma

Doucet M et al. (2007-05-03), Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med., 2007-0176(3):261-9.
PMID: 17478621
Species: Human
Sample Types: Serum

Lorenzo-Zuniga V et al. (2007-04-05), Serum concentrations of insulin-like growth factor-I (igf-I) as a marker of liver fibrosis in patients with chronic hepatitis C. Dig. Dis. Sci., 2007-052(11):3245-50.
PMID: 17410466
Species: Human
Sample Types: Serum

Schoyer KD et al. (2007-02-22), Serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3) in IVF patients with polycystic ovary syndrome: correlations with outcome. Fertil. Steril., 2007-088(1):139-44.
PMID: 17320874
Species: Human
Sample Types: Plasma

Yin D et al. (2007-02-01), Clinical pharmacodynamic effects of the growth hormone receptor antagonist pegvisomant: implications for cancer therapy. Clin. Cancer Res., 2007-013(3):1000-9.
PMID: 17289896
Species: Human
Sample Types: Follicular Fluid

Wang TH et al. (2006-11-01), Insulin-like growth factor-II (IGF-II), IGF-binding protein-3 (IGFBP-3), and IGFBP-4 in follicular fluid are associated with oocyte maturation and embryo development. Fertil. Steril., 2006-186(5):1392-401.
PMID: 17070193
Species: Human
Sample Types: Tissue Homogenates

Herrmann S et al. (2006-07-25), Quantitative assessment of growth factors in reaming aspirate, iliac crest, and platelet preparation. Bone, 2006-039(5):1156-63.
PMID: 16863704
Species: Human
Sample Types: Cell Culture Supernates

Moreno MJ et al. (2006-06-01), Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells. Glia, 2006-053(8):845-57.
PMID: 16586492
Species: Human
Sample Types: Cell Culture Supernates

Hanley MB et al. (2005-06-13), Growth hormone-induced stimulation of multilineage human hematopoiesis. Stem Cells, 2005-023(8):1170-9.
PMID: 15955828
Species: Human
Sample Types: Recombinant Protein

Escartin C et al. (2004-10-05), Insulin growth factor-1 protects against excitotoxicity in the rat striatum. Neuroreport, 2004-115(14):2251-4.
PMID: 15371744
Species: Porcine
Sample Types: Plasma

Blanaru JL et al. (2004-01-01), Dose response of bone mass to dietary arachidonic acid in piglets fed cow milk-based formula. Am. J. Clin. Nutr., 2004-079(1):139-47.
PMID: 14684410
Sample Types: Tissue Homogenates

Blum B et al. (2004-01-01), Measurement of bone morphogenetic proteins and other growth factors in demineralized bone matrix. Orthopedics, 2004-027(1):161-5.
PMID: 14763551

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Human IGF-I/IGF-1 Quantikine ELISA Kit

Human IGF-I/IGF-1 Quantikine ELISA Kit

Human IGF-I/IGF-1 Quantikine ELISA Kit

Human IGF-I/IGF-1 Quantikine ELISA Kit

Human IGF-I/IGF-1 Quantikine ELISA Kit

Human IGF-I/IGF-1 Quantikine ELISA Kit

Human IGF-I/IGF-1 Quantikine ELISA Kit

Human IGF-I/IGF-1 Quantikine ELISA Kit

Human IGF-I/IGF-1 Quantikine ELISA Kit

Human IGF-I/IGF-1 Quantikine ELISA Kit

Human IGF-I/IGF-1 Quantikine ELISA Kit

Human IGF-I/IGF-1 Quantikine ELISA Kit

Human IGF-I/IGF-1 Quantikine ELISA Kit

Human IGF-I/IGF-1 Quantikine ELISA Kit

Human IGF-I/IGF-1 Quantikine ELISA Kit

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