VH 032, amine
Tocris Bioscience, part of Bio-Techne | Catalog # 6462
Functionalized VHL ligand for PROTACs
Key Product Details
Description
Functionalized VHL ligand for PROTACs
Product Description
VH 032, amine is a derivative of the von Hippel-Lindau (VHL) ligand, VH 032; commonly used as a precursor to a PROTAC® that hijacks VHL as the E3 ubiquitin ligase component. Supplied with a primary amine functional handle at a position known not to significantly affect binding to VHL, for ready conjugation to a linker/target protein ligand.Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
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Usage Guidelines
This product is provided for use in onward chemistry. Suitable solvents can be used.Product Specifications
Molecular Weight
503.49
Formula
C22H30N4O3S.2HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide dihydrochloride
CAS Number
2137142-47-1
PubChem ID
118864076
InChI Key
SADPMNNWFOJMCY-ZNZDOTFASA-N
SMILES
CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)N)=O)O)=O)SC=N1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Galdeano Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities. J.Med.Chem.
- Zengerle Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS Chem.Biol. 2015 PMID: 26035625
Product Specific Notices for VH 032, amine
For research use only
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