NBI 35965 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3100
Potent and selective CRF1 antagonist
Key Product Details
Description
Potent and selective CRF1 antagonist
Product Description
NBI 35965 hydrochloride is a potent and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist (Ki values are 4 and > 10000 nM at CRF1 and CRF2 respectively). Inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro (pIC50 values are 7.1 and 6.9 respectively) and attenuates CRF and ACTH production in vivo. Orally active and brain penetrant with anxiolytic activity.Product Specifications
Molecular Weight
437.79
Formula
C21H22Cl2N4.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(7S)-6-(Cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene hydrochloride
CAS Number
1782228-59-4
PubChem ID
71433630
InChI Key
LNYUWBPFYXPUIO-RSAXXLAASA-N
SMILES
CC[C@@H]3N(CC5CC5)C1=C2C(C(C4=CC=C(Cl)C=C4Cl)=NN2C3)=NC(C)=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 43.78 | 100 | |
| DMSO | 43.78 | 100 |
Preparing Stock Solutions
for NBI 35965 hydrochloride
The following data is based on the product molecular weight 437.79
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.28 mL | 11.42 mL | 22.84 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.57 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.28 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hoare Mechanism of corticotropin-releasing factor type I receptor regulation by non-peptide antagonists. Mol.Pharmacol. 2003 PMID: 12606786
- Gross Design and synthesis of tricyclic corticotropin-releasing factor-1 antagonists. J.Med.Chem. 2005 PMID: 16134945
- Million A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats. Brain Res. 2003 PMID: 12957366
Product Specific Notices for NBI 35965 hydrochloride
For research use only
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