Rat AGTR1b (NP_112271.2) VersaClone cDNA

R&D Systems, part of Bio-Techne | Catalog # RDC2992

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Key Product Details

Species

Rat

Accession Number

NP_112271.2

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: AGTR1b

The Angiotensin II Receptor, Type 1 (AGTR-1), also known as AT1, is a member of a family of seven transmembrane G protein-coupled receptors that mediates the effects of Angiotensin II, the major bioactive peptide of the renin-angiotensin system. AGTR-1 is 359 amino acids (aa) in length with a predicted molecular weight of 41.1 kDa. Human AGTR-1 shares 94% and 95% aa sequence identity with mouse and rat orthologs, respectively. Interestingly, most species express a single AGTR-1 gene while rodents contain two related genes, which are termed AGTR-1A and AGTR-1B. AGTR-1 is widely expressed with the highest levels being found in the liver, kidney, adrenal glands, brain, heart, vasculature, and lungs. It is coupled to G proteins containing the alphaq/11 subunits and has been shown to activate the PLC-IP3-Ca2+ and PLC-DAG-PKC, MAPK, and Jak/STAT signal transduction pathways. AGTR-1 has been shown to mediate most of the physiological actions of Angiotensin II including vasoconstriction, aldosterone and vasopressin release, salt and water retention, cell proliferation and migration, and sympathetic stimulation. Additionally, AGTR-1 has been suggested to play a role in the induction of reperfusion arrhythmias. AGTR-1 antagonists are used to treat hypertension, diabetic nephropathy, and congestive heart failure.

Long Name

Angiotensin II Receptor Type 1b

Entrez Gene IDs

81638 (Rat)

Gene Symbol

AGTR1B

UniProt

NP_112271.2

Additional AGTR1b Products

Product Documents for Rat AGTR1b (NP_112271.2) VersaClone cDNA

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Product Specific Notices for Rat AGTR1b (NP_112271.2) VersaClone cDNA

For research use only

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