Mouse CLEC-2/CLEC1B (NP_064369) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC2577
Key Product Details
Species
Mouse
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: CLEC-2/CLEC1B
CLEC-2 (C-type lectin-like receptor 2), also known as CLEC-1B, is a transmembrane glycoprotein that is expressed on platelets, megakaryocyte, and liver sinusoidal cells. CLEC-2 binding to Podoplanin triggers platelet activation, shedding of GPVI, and cleavage of Fcgamma RIIA/CD32a. CLEC-2 expression on platelets is required for the development of lymphatic vessels and valves as well as the maintenance of lymph node high endothelial veinules (HEV) during lymphocyte crossing. CLEC-2 additionally binds to fucoidan, HIV-1, and the platelet-aggregating snake venom protein Rhodocytin/Aggretin. In the liver, soluble CLEC-2 promotes M2 macrophage differentiation and limits inflammatory cytokine production.
Long Name
C-type Lectin-like Receptor 2
Alternate Names
CLEC1B, CLEC2
Gene Symbol
CLEC1B
UniProt
Additional CLEC-2/CLEC1B Products
Product Documents for Mouse CLEC-2/CLEC1B (NP_064369) VersaClone cDNA
Product Specific Notices for Mouse CLEC-2/CLEC1B (NP_064369) VersaClone cDNA
For research use only
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