Human Wnt-5b (NP_110402.2) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC3710
Key Product Details
Species
Human
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: Wnt-5b
Wnt-5b is a 49 kDa glycoprotein of the subgroup of Wnts that is implicated in the non-canonical Wnt/Ca2+ pathway. Wnt-5b is not axis-inducing in Xenopus embryos and only weakly transforms C57MG mammary epithelial cells. In adult mice, Wnt-5b is expressed in heart, liver, brain, lung, testes, kidney, and pancreas. Wnt-5b appears to promote adipogenesis and is upregulated in early adipogenesis. Also, Wnt-5b overexpression in 3T3-L1 cells partially inhibits canonical Wnt suppression of adipogenesis.
Human Wnt-5b polymorphisms have been associated with Type II diabetes. Although Wnt-5a and Wnt-5b share 83% amino acid identity, they show differential expression and regulation of cyclin D1 and p130 during endochondral bone development. Together, Wnt-5a and Wnt-5b appear to coordinate chondrocyte proliferation and differentiation. The expression of Wnt-5a and Wnt-5b are also implicated in limb development. Mature mouse Wnt-5b shows 94%, 98%, 90% and 88% amino acid identity with mature human, rat, chick and Xenopus Wnt-5b, respectively.
Long Name
Wingless-type MMTV Integration Site Family, Member 5b
Alternate Names
Wnt5b
Gene Symbol
WNT5B
UniProt
Additional Wnt-5b Products
Product Documents for Human Wnt-5b (NP_110402.2) VersaClone cDNA
Product Specific Notices for Human Wnt-5b (NP_110402.2) VersaClone cDNA
For research use only
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