Human MAG/Siglec-4a (NP_002352) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC1566
Key Product Details
Species
Human
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: MAG/Siglec-4a
MAG (Myelin-Associated Glycoprotein), also known as Siglec-4a, is a transmembrane lectin that preferentially binds to alpha-2,3-linked sialic acid terminal carbohydrates on cell surface molecules. It is expressed by myelinating oligodendrocytes and Schwann cells and plays an important role in axon-myelin stability. MAG also regulates axon structure at nodes of Ranvier, inhibits neurite outgrowth, and protects neurons from excitotoxicity. It interacts with the gangliosides GD1a and GT1b, the Nogo receptors NgR1 and NgR2/NgRH1, Integrin beta 1/CD29, and PIR-B. Proteolytic cleavage releases a soluble form that is released from myelin in large quantities.
Long Name
Myelin-associated Glycoprotein
Alternate Names
Siglec-4a, Siglec4a
Gene Symbol
MAG
UniProt
Additional MAG/Siglec-4a Products
Product Documents for Human MAG/Siglec-4a (NP_002352) VersaClone cDNA
Product Specific Notices for Human MAG/Siglec-4a (NP_002352) VersaClone cDNA
For research use only
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