Human Kirrel1/NEPH1 (NP_060710) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC1886
Key Product Details
Species
Human
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: Kirrel1/NEPH1
Kirrel (kin of irregular chiasm-1-like) proteins, also known as the NEPH (nephrin-like) family, are type I transmembrane glycoproteins within the immunoglobulin superfamily. Kirrel1 (NEPH1), Kirrel2 (NEPH3, Filtrin, NLG-1) and Kirrel3 (NEPH2, kirre) share 34 - 44% amino acid (aa) identity, and all interact with nephrin, podocin and the adaptor molecule ZO-1 (1, 4). All can be found in podocytes of the kidney glomerulus, and play a role in barrier function in the slit diaphragm. (2-6). Kirrel1 can also be found in central nervous system neurons, pancreas and placenta, Kirrel2 in pancreatic islet beta cells, brain and lymph nodes, and Kirrel3 in the brain and bone marrow, typically at sites where nephrin is also expressed.
Long Name
Kin of Irregular Chiasm-like 1
Alternate Names
KIRREL, NEPH1
Gene Symbol
KIRREL1
UniProt
Additional Kirrel1/NEPH1 Products
Product Documents for Human Kirrel1/NEPH1 (NP_060710) VersaClone cDNA
Product Specific Notices for Human Kirrel1/NEPH1 (NP_060710) VersaClone cDNA
For research use only
Loading...
Loading...
Loading...