Human GPR37 (NP_005293) VersaClone cDNA

R&D Systems, part of Bio-Techne | Catalog # RDC0066

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Key Product Details

Species

Human

Accession Number

NP_005293

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: GPR37

GPR37 is an Orphan-A GPCR with an unknown ligand. GPR37 was recently identified as the PAEL receptor, a Parkin substrate involved in autosomal recessive juvenile Parkinson's (PDJ) disease. The PAEL receptor becomes unfolded, insoluble, and ubiquitinated when overexpressed, leading to unfolded protein-induced cell death. When the PAEL receptor is ubiquitinated by Parkin, it gets degraded, resulting in the suppression of cell death. The insoluble form of the PAEL receptor accumulates in the brains of PDJ patients and may cause selective neuronal death. GPR37 expression has been reported in brain, liver, and placenta. ESTs have been isolated from brain, embryo, eye, fetal lung/testis/Bcell, gallbladder, heart, liver, liver/spleen, melanocyte/uterus/fetal heart, nerve, placenta, testis, tonsil, and vessel libraries.

Long Name

G Protein-coupled Receptor 37

Alternate Names

ETBR-LP-1, PAELR

Entrez Gene IDs

2861 (Human); 14763 (Mouse); 117549 (Rat)

Gene Symbol

GPR37

UniProt

NP_005293

Additional GPR37 Products

Product Documents for Human GPR37 (NP_005293) VersaClone cDNA

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Certificate of Analysis

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Product Specific Notices for Human GPR37 (NP_005293) VersaClone cDNA

For research use only

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