Human GDF-5/BMP-14 (AAH32495.1) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC3532
Key Product Details
Species
Human
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: GDF-5/BMP-14
Growth Differentiation Factor-5, also known as BMP-14 and CDMP-1, is a member of the BMP family of TGF-beta superfamily proteins. GDF-5 signaling is mediated by formation of a heterodimeric complex consisting of a type 1 (BMPR-IB) and a type II (BMPR-II or Activin RII) serine/threonine kinase receptor which results in the phosphorylation and activation of cytosolic Smad proteins (Smad1, 5, and 8). Its signaling is antagonized by Noggin. GDF-5 is involved in multiple developmental processes including limb generation, cartilage development, joint formation, bone morphogenesis, cell survival, and neuritogenesis. GDF-5 can promote chondrogenesis, osteogenesis, and angiogenesis in mesenchymal stem cells.
Long Name
Growth Differentiation Factor 5
Alternate Names
BMP-14, CDMP-1, GDF5
Gene Symbol
GDF5
UniProt
Additional GDF-5/BMP-14 Products
Product Documents for Human GDF-5/BMP-14 (AAH32495.1) VersaClone cDNA
Product Specific Notices for Human GDF-5/BMP-14 (AAH32495.1) VersaClone cDNA
For research use only
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