Human EAAT2/GLT1 (NP_001239581) VersaClone cDNA

R&D Systems, part of Bio-Techne | Catalog # RDC0875

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Key Product Details

Species

Human

Accession Number

NP_001239581

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: EAAT2/GLT1

GLT1 is the major glial glutamate transporter that takes up more than 90% of glutamate from the synapse. GLT1b is a splice variant that contains 11 unique amino acids at the C-terminus that encode a PDZ binding domain. GLT1b was initially believed to be the neuronal isoform of GLT1, but it now appears that GLT1b is localized to astrocytes in the normal brain and to neurons in pathological conditions. In Lou Gehrig's Disease, GLT1a is decreased, while GLT1b is increased. There are also different expressions in hypoxic cells, which have not yet been fully elucidated.

Long Name

Excitatory Amino Acid Transporter 2

Alternate Names

EAAT2, GLT1, SLC1A2

Entrez Gene IDs

6506 (Human)

Gene Symbol

SLC1A2

UniProt

NP_001239581

Additional EAAT2/GLT1 Products

Product Documents for Human EAAT2/GLT1 (NP_001239581) VersaClone cDNA

Product Datasheets

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Product Specific Notices for Human EAAT2/GLT1 (NP_001239581) VersaClone cDNA

For research use only

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