Human BST-2/Tetherin (NP_004326) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC2088
Key Product Details
Species
Human
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: BST-2/Tetherin
BST2, also known as CD317, Tetherin, and PDCA1, is a 30-35 kDa interferon-inducible protein that associates with the plasma membrane with its transmembrane segment and GPI anchor. BST2 is expressed on bone marrow stromal cells and is upregulated in breast cancer and astrocytoma. It binds to ILT7 on plasmacytoid dendritic cells and inhibits proinflammatory TLR7 and TLR9 signaling. BST2 inhibits the release of Kaposi sarcoma virus, HIV-1, and Lassa virus from infected cells, but this function is counteracted by viral proteins which directly bind and trigger the degradation of BST2.
Long Name
Bone Marrow Stromal Cell Antigen 2
Alternate Names
BST2, CD317, HM1.24 Antigen, NPC-A-7, Tetherin
Gene Symbol
BST2
UniProt
Additional BST-2/Tetherin Products
Product Documents for Human BST-2/Tetherin (NP_004326) VersaClone cDNA
Product Specific Notices for Human BST-2/Tetherin (NP_004326) VersaClone cDNA
For research use only
Loading...
Loading...
Loading...