Human BMP-3 (NP_001192) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC2415
Key Product Details
Species
Human
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: BMP-3
BMP-3, also known as Osteogenin, is a homodimeric cytokine and the most abundant bone morphogenetic protein in adult bone. The role of BMP-3 in bone is complex. It inhibits alkaline phosphatase production and induction of osteoblastic target genes in undifferentiated mesenchymal and osteogenic cell lines that have been treated with BMP-2. BMP-3 also induces the expression of TGF-beta/Activin responsive genes but not BMP-responsive genes. Since the inhibitory effect is not due to direct competition with osteogenic BMPs, BMP-3 may activate signaling through an Activin pathway, resulting in antagonism of osteogenesis induced by other BMPs. In addition, BMP-3 dorsalizes Xenopus embryos, the opposite effect of BMP-2 or 4, which cause ventralization.
Long Name
Bone Morphogenetic Protein 3
Alternate Names
BMP3, Osteogenin
Gene Symbol
BMP3
UniProt
Additional BMP-3 Products
Product Documents for Human BMP-3 (NP_001192) VersaClone cDNA
Product Specific Notices for Human BMP-3 (NP_001192) VersaClone cDNA
For research use only
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