Human beta-Arrestin 2 (NP_004304.1) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC3623
Key Product Details
Species
Human
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: beta-Arrestin 2
The Arrestin family consists of four members: Arrestin 1 (visual Arrestin), Arrestin 2 (beta-Arrestin 1), Arrestin 3 (beta-Arrestin 2), and Arrestin 4 (cone Arrestin). While visual and cone Arrestins are found almost exclusively in the retina, beta-Arrestins 1 and 2 are ubiquitously expressed, and were initially described as negative regulators of G protein-coupled receptor (GPCR) signaling.
More recently, beta-Arrestins have been determined to serve as scaffolds for various signaling pathways, including the MAPK cascades activating ERK2, p38a, and JNK3. These beta-Arrestin scaffolds tie together the appropriate kinases in series, forming a discreet signaling module that localizes components to specific subcellular environments and facilitates greater kinase activation.
Alternate Names
ARB2, ARR2, ARRB2, betaArrestin 2
Gene Symbol
ARRB2
UniProt
Additional beta-Arrestin 2 Products
Product Documents for Human beta-Arrestin 2 (NP_004304.1) VersaClone cDNA
Product Specific Notices for Human beta-Arrestin 2 (NP_004304.1) VersaClone cDNA
For research use only
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