Human B7-H4 (NP_078902) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC0687
Key Product Details
Species
Human
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: B7-H4
B7-H4, also known as B7x and B7S1, is an immune costimulatory protein that is expressed on the surface of activated lymphocytes, macrophages, monocytes, dendritic cells, epithelial cells, and bone marrow-derived mesenchymal stem cells. Its binding to activated T cells dampens T cell responses and induces cell cycle arrest in the T cell. Reverse signaling can induce either cell cycle arrest or apoptosis in the B7-H4 expressing cell. B7-H4 is upregulated in several carcinomas in correlation with tumor progression and metastasis. A soluble form of B7-H4 functions as a decoy molecule and is elevated in the serum of ovarian cancer, renal cell carcinoma, and rheumatoid arthritis patients.
Long Name
B7 Homolog 4
Alternate Names
B7H4, B7S1, B7x, Vtcn1
Gene Symbol
VTCN1
UniProt
Additional B7-H4 Products
Product Documents for Human B7-H4 (NP_078902) VersaClone cDNA
Product Specific Notices for Human B7-H4 (NP_078902) VersaClone cDNA
For research use only
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