Human AMPK gamma 3 (NP_059127) VersaClone cDNA

R&D Systems, part of Bio-Techne | Catalog # RDC2311

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Key Product Details

Species

Human

Accession Number

NP_059127

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: AMPK gamma 3

AMP-activated protein kinase (AMPK) is a heterotrimeric complex consisting of a catalytic a subunit and regulatory beta and gamma subunits. Each subunit exists as alternate isoforms (alpha 1, alpha 2, beta 1, beta 2, gamma 1, gamma 2, gamma 3), with all 12 combinations capable of forming complexes. The catalytic a subunit of AMPK is activated allosterically by AMP and by phosphorylation via the AMPK kinase LKB1. Active AMPK downregulates anabolic pathways such as fatty acid, triglyceride, and cholesterol synthesis, and up-regulates catabolic pathways such as glycolysis and fatty acid oxidation. AMPK's role in metabolic regulation has implicated this serine/threonine kinase as a therapeutic target in heart disease, obesity, and diabetes.

Long Name

AMP-activated Protein Kinase gamma 3

Alternate Names

AMPKG3, PRKAG3

Entrez Gene IDs

53632 (Human); 241113 (Mouse); 301518 (Rat)

Gene Symbol

PRKAG3

UniProt

NP_059127

Additional AMPK gamma 3 Products

Product Documents for Human AMPK gamma 3 (NP_059127) VersaClone cDNA

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Product Specific Notices for Human AMPK gamma 3 (NP_059127) VersaClone cDNA

For research use only

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