LEI 101 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5826
Potent and selective CB2 partial agonist; orally biovailable
Key Product Details
Description
Potent and selective CB2 partial agonist; orally biovailable
Product Description
LEI 101 hydrochloride is a potent and selective CB2 partial agonist (pEC50 = 8.0). Exhibits >100-fold selectivity for CB2 over CB1 and no significant interaction with hFAAH, MAGL, DAGL or NAPE-PLD. Displays antinociceptive activity in a rat neuropathic pain model and attenuates renal inflammation in a mouse kidney damage model. Orally bioavailable with low brain penetration.Product Specifications
Molecular Weight
508.99
Formula
C23H25FN4O4S.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-Cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-2,4-imidazolidinedione hydrochloride
CAS Number
2250025-91-1
PubChem ID
127021038
InChI Key
APLLNJWPLUIBCG-UHFFFAOYSA-N
SMILES
FC1=CC=C(C2=CC=C(C=C2)CN3CC(N(C3=O)C4CC4)=O)N=C1CN5CCS(=O)(CC5)=O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.9 | 100 |
Preparing Stock Solutions
for LEI 101 hydrochloride
The following data is based on the product molecular weight 508.99
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.96 mL | 9.82 mL | 19.65 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.93 mL |
| 10 mM | 0.20 mL | 0.98 mL | 1.96 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mukhopadhyay The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity. Br.J.Pharmacol. 2016 PMID: 26398481
- van der Stelt M Discovery and optimization of 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives as a novel class of selective cannabinoid CB2 receptor agonists. J.Med.Chem. 2011 PMID: 21923175
Product Specific Notices for LEI 101 hydrochloride
For research use only
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