JNJ DGAT2-A
Tocris Bioscience, part of Bio-Techne | Catalog # 5853
DGAT2 inhibitor
Key Product Details
Description
DGAT2 inhibitor
Product Description
JNJ DGAT2-A is a DGAT2 inhibitor (IC50 = 140 nM). Exhibits >70-fold selectivity for DGAT2 over DGAT1 and MGAT2.Product Specifications
Molecular Weight
523.38
Formula
C24H16BrFN4O2S
Storage
Store at +4°C
Chemical Name
3-Bromo-4-[2-fluoro-4-[[4-oxo-2-[[2-(pyridin-2-yl)ethyl]amino]-1,3-thiazol-5-(4H)ylidene]methyl]phenoxy]benzonitrile
CAS Number
1962931-71-0
PubChem ID
101578741
InChI Key
ZFRHAMOJHTZHLT-LPYMAVHISA-N
SMILES
BrC1=C(OC2=C(F)C=C(/C=C3\SC(NCCC4=CC=CC=N4)=NC3=O)C=C2)C=CC(C#N)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.34 | 100 |
Preparing Stock Solutions
for JNJ DGAT2-A
The following data is based on the product molecular weight 523.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.91 mL | 9.55 mL | 19.11 mL |
| 5 mM | 0.38 mL | 1.91 mL | 3.82 mL |
| 10 mM | 0.19 mL | 0.96 mL | 1.91 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Irshad Diacylglycerol acyltransferase 2 links glucose utilization to fatty acid oxidation in the brown adipocytes. J.Lipid Res. 2017 PMID: 27836993
- Qi The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2 J.Lipid Res. 2012 PMID: 22493088
Product Specific Notices for JNJ DGAT2-A
For research use only
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