TG 003
Tocris Bioscience, part of Bio-Techne | Catalog # 4336
Potent inhibitor of Clk-family kinases; also inhibits DYRK1A/B
Key Product Details
Description
Potent inhibitor of Clk-family kinases; also inhibits DYRK1A/B
Product Description
TG 003 is a potent, ATP-competitive inhibitor of Clk-family kinases (IC50 values are 15, 20 and 200 nM for mClk4, 1 and 2 respectively and >10 μM for mClk3). Also inhibits DYRK1A/B (IC50 values are 24 and 34 nM respectively). Suppresses serine/arginine-rich protein phosphorylation; affects the regulation of alternative splicing by phosphorylation of SR protein both in vitro and in vivo.Product Specifications
Molecular Weight
249.33
Formula
C13H15NO2S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(1Z)-1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone
CAS Number
719277-26-6
PubChem ID
647991
InChI Key
BGVLELSCIHASRV-UHFFFAOYSA-N
SMILES
O=C(C)/C=C1SC2=CC=C(OC)C=C2N\1CC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.93 | 100 | |
| Ethanol | 18.7 | 75 |
Preparing Stock Solutions
for TG 003
The following data is based on the product molecular weight 249.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.01 mL | 20.05 mL | 40.11 mL |
| 5 mM | 0.80 mL | 4.01 mL | 8.02 mL |
| 10 mM | 0.40 mL | 2.01 mL | 4.01 mL |
| 50 mM | 0.08 mL | 0.40 mL | 0.80 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Foucourt Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part II. Molecules 2014 PMID: 25264830
- Muraki Manipulation of alternative splicing by a newly developed inhibitor of Clks. J.Biol.Chem. 2004 PMID: 15010457
Product Specific Notices for TG 003
For research use only
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