Viral HHV8-ORF74 Antibody
R&D Systems, part of Bio-Techne | Catalog # MAB5264
Conjugate
Catalog #
Key Product Details
Species Reactivity
Viral
Applications
CyTOF-ready, Flow Cytometry
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG2B Clone # 462510
Product Specifications
Immunogen
NS0 mouse myeloma cell line transfected with viral HHV8-ORF74
Met1-Thr342
Accession # AAB51506
Met1-Thr342
Accession # AAB51506
Specificity
Detects viral HHV8-ORF74.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2B
Applications for Viral HHV8-ORF74 Antibody
Application
Recommended Usage
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
Flow Cytometry
2.5 µg/106 cells
Sample: NS0 mouse myeloma cell line transfected with viral HHV8-ORF74
Sample: NS0 mouse myeloma cell line transfected with viral HHV8-ORF74
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: HHV8-ORF74
HHV8‑ORF74 is a 342 amino acid viral 7-transmembrane receptor encoded by the Kaposi's sarcoma-associated herpesvirus 8. The G‑protein-coupled receptor is a constitutively active homologue of CXCR2, the CXCL8 receptor (IL-8 RB). It contributes to Kaposi's sarcoma by triggering expression of paracrine factors such as VEGF-A, inflammatory cytokines, adhesion molecules and chemokines, and enhancing cell growth.
Long Name
Human Herpesvirus 8 ORF74
Alternate Names
HHV8ORF74, KSHV-vGPCR
Entrez Gene IDs
4961460 (Viral)
Gene Symbol
HHV8GK18_GP84
UniProt
Additional HHV8-ORF74 Products
Product Documents for Viral HHV8-ORF74 Antibody
Product Specific Notices for Viral HHV8-ORF74 Antibody
For research use only
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