uPAR Antibody (VIM-5) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-11408

Novus Biologicals, part of Bio-Techne
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NBP3-11408-0.025mg
NBP3-11408-0.1mg
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Frozen, Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG Clone # VIM-5

Format

BSA Free

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all uPAR Antibodies »

Product Specifications

Immunogen

THP-1 cells (Human acute monocytic leukaemia cells)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG

Applications for uPAR Antibody (VIM-5) - BSA Free

Application
Recommended Usage

Flow Cytometry

1:50 - 1:200

Immunohistochemistry-Frozen

1:100
Application Notes
For Flow cytometry: Use 10 uL of the suggested working dilution to label 1x10^6 cells in 100 uL.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: uPAR

The urokinase-type plasminogen activator (uPA) is one of two activators that converts the extracellular zymogen plasminogen to plasmin, a serine protease that is involved in a variety of normal and pathological processes that require cell migration and/or tissue destruction. uPA is synthesized and released from cells as a single-chain (sc) pro-enzyme with limited enzymatic activity and is converted to an active two-chain (tc) disulfide-linked active enzyme by plasmin and other specific proteinases. Both the scuPA and tcuPA bind with high-affinity to the cell surface via the glycosyl phosphatidylinositol-linked receptor uPAR which serves to localize the uPA proteolytic activity. The enzymatic activity of scuPA has also been shown to be enhanced by binding to uPAR. Independent of their proteolytic activity, the uPA/uPAR interaction also initiates signal transduction responses resulting in activation of protein tyrosine kinases, gene expression, cell adhesion, and chemotaxis. uPAR can interact with integrins to suppress normal integrin adhesive function and promote adhesion to vitronectin through a high affinity vitronectin binding site on uPAR.

Long Name

Urokinase-type Plasminogen Activator Receptor

Alternate Names

PLAUR

Gene Symbol

PLAUR

UniProt

Q03405

Additional uPAR Products

Product Documents for uPAR Antibody (VIM-5) - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for uPAR Antibody (VIM-5) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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