TSC2 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76619

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NBP1-76619
NBP1-76619-0.025mg
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Conjugate
Catalog #
Alexa Fluor 350
NBP1-76619AF350
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Alexa Fluor 405
NBP1-76619AF405
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Alexa Fluor 488
NBP1-76619AF488
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Alexa Fluor 532
NBP1-76619AF532
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Alexa Fluor 594
NBP1-76619AF594
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Alexa Fluor 647
NBP1-76619AF647
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Alexa Fluor 700
NBP1-76619AF700
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Alexa Fluor 750
NBP1-76619AF750
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Alexa Fluor Plus 405
NBP1-76619AFP405
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Alexa Fluor Plus 488
NBP1-76619AFP488
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Alexa Fluor Plus 555
NBP1-76619AFP555
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Alexa Fluor Plus 594
NBP1-76619AFP594
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Alexa Fluor Plus 647
NBP1-76619AFP647
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Alexa Fluor Plus 680
NBP1-76619AFP680
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Allophycocyanin
NBP1-76619APC
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Biotin
NBP1-76619B
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CoraFluor 1
NBP1-76619CL1
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DyLight 350
NBP1-76619UV
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DyLight 405
NBP1-76619V
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DyLight 488
NBP1-76619G
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DyLight 550
NBP1-76619R
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DyLight 594
NBP1-76619DL594
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DyLight 650
NBP1-76619C
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DyLight 680
NBP1-76619FR
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DyLight 755
NBP1-76619IR
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FITC
NBP1-76619F
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HRP
NBP1-76619H
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Janelia Fluor 525
NBP1-76619JF525
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Janelia Fluor 549
NBP1-76619JF549
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Janelia Fluor 646
NBP1-76619JF646
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Janelia Fluor 669
NBP1-76619JF669
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mFluor Violet 450 SE
NBP1-76619MFV450
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mFluor Violet 500 SE
NBP1-76619MFV500
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mFluor Violet 610 SE
NBP1-76619MFV610
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PE
NBP1-76619PE
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PerCP
NBP1-76619PCP
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all TSC2 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human TSC2. The immunogen is located within the first 50 amino acids of TSC2.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Rat (86%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TSC2 Antibody - BSA Free

Western Blot: TSC2 AntibodyBSA Free [NBP1-76619]

Western Blot: TSC2 AntibodyBSA Free [NBP1-76619]

Western Blot: TSC2 Antibody [NBP1-76619] - Analysis of TSC2 in L1210 cell lysate with TSC2 antibody at (A) 2 and (B) 4 ug/mL.

Immunocytochemistry/Immunofluorescence: TSC2 Antibody [NBP1-76619] -

Immunocytochemistry/Immunofluorescence: TSC2 Antibody [NBP1-76619] - L1210 cells with TSC2 antibody at 10 ug/ml.
TSC2 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: TSC2 Antibody - BSA Free [NBP1-76619] -

Immunocytochemistry/ Immunofluorescence: TSC2 Antibody - BSA Free [NBP1-76619] - Immunofluorescence of TSC2 in L1210 cells with TSC2 antibody at 20 ug/mL.

Applications for TSC2 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

10-20 ug/mL

Western Blot

2-4 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TSC2

Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 complex decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing that overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. At least three isoforms of TSC2 exist.

Long Name

Tuberous Sclerosis 2

Alternate Names

LAM, TSC4, Tuberin

Gene Symbol

TSC2

UniProt

NP_000539 (Human)

Additional TSC2 Products

Product Documents for TSC2 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TSC2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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