TGF-beta 3 Biotinylated Antibody
R&D Systems, part of Bio-Techne | Catalog # BAM643
Conjugate
Catalog #
Key Product Details
Species Reactivity
Multi-Species
Applications
Western Blot
Label
Biotin
Antibody Source
Monoclonal Mouse IgG1 Clone # 44922
Product Specifications
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human TGF-beta 3
Ala301-Ser412 (Tyr340Phe)
Accession # NP_003230.1
Ala301-Ser412 (Tyr340Phe)
Accession # NP_003230.1
Specificity
Detects TGF-beta 3 in Western blots. In Western blots, this antibody shows approximately 10% cross-reactivity with recombinant human (rh) TGF‑ beta2, 5% with rhTGF‑ beta1.2, and no cross-reactivity with rhTGF-alpha, rhTGF-beta 1, rhART, rhGDNF, rhLAP, rhNeuritin, or rhLefty.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1
Applications for TGF-beta 3 Biotinylated Antibody
Application
Recommended Usage
Western Blot
1 µg/mL
Sample: Recombinant Human TGF-beta 3 (Catalog # 243-B3)
under non-reducing conditions only
Sample: Recombinant Human TGF-beta 3 (Catalog # 243-B3)
under non-reducing conditions only
Reviewed Applications
Read 1 review rated 4 using BAM643 in the following applications:
Formulation, Preparation, and Storage
Purification
Protein A or G purified from ascites
Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: TGF-beta 3
TGF-beta 3 (transforming growth factor beta 3) Is a pleiotropic cytokine that regulates immune function, proliferation, and epithelial-mesenchymal transition. Disulfide-linked homodimers of LAP and TGF-beta 3 remain non-covalently associated after secretion, forming the small latent TGF-beta 3 complex. Covalent linkage of LAP to one of three latent TGF-beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix. Bioactive TGF-beta is released by proteolytic cleavage. TGF-beta 3 signals through a receptor complex containing TGF-beta RII and either TGF-beta RI/ALK5 or ALK1.
Long Name
Transforming Growth Factor beta 3
Alternate Names
ARVD1, LDS5, RNHF, TGFB3, TGFbeta 3
Gene Symbol
TGFB3
UniProt
Additional TGF-beta 3 Products
Product Documents for TGF-beta 3 Biotinylated Antibody
Product Specific Notices for TGF-beta 3 Biotinylated Antibody
For research use only
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