SPINK5 Antibody [DyLight 405]
Novus Biologicals, part of Bio-Techne | Catalog # AF8515E
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
DyLight 405 (Excitation = 400 nm, Emission = 420 nm)
Antibody Source
Polyclonal Rabbit IgG
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
Human embyronic kidney cell line HEK293-derived recombinant human SPINK5
Glu626-Glu1064
Accession # Q9NQ38
Glu626-Glu1064
Accession # Q9NQ38
Specificity
Detects human SPINK5 in direct ELISAs and Western blots.
Clonality
Polyclonal
Host
Rabbit
Isotype
IgG
Applications for SPINK5 Antibody [DyLight 405]
Application
Recommended Usage
Western Blot
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Antigen Affinity-purified
Formulation
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: LEKTI/SPINK5
LEKTI, encoded by the SPINK5 gene, is a serine proteinase inhibitor with activity toward Kallikreins, Plasmin, Subtilisin A, Cathepsin G, Elastase, and Trypsin. It is primarily expressed in differentiated keratinocytes and is found in multiple forms due to alternative splicing and proteolytic cleavage. In the skin, LEKTI regulates the ability of KLK5, KLK7, and KLK14 to degrade the desmosomal proteins Desmoglein-1 and Desmoplakin-1 during desquamation. Mutations in SPINK5 and loss of its expression are associated with the development of various skin disorders such as Netherton syndrome, atopic eczema, and atopic dermatitis.
Long Name
Serine Peptidase Inhibitor, Kazal Type 5
Alternate Names
LETKI, NETS, SPINK5, VAKTI
Gene Symbol
SPINK5
Additional LEKTI/SPINK5 Products
Product Documents for SPINK5 Antibody [DyLight 405]
Product Specific Notices for SPINK5 Antibody [DyLight 405]
DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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