RB1 [p Ser780] Antibody (24GB3950)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-50761

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NBP3-50761-100ul
NBP3-50761-20ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 24GB3950

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all RB1 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human Phospho-RB1 (S780) (Uniprot: P06400)

Modification

p Ser780

Specificity

This antibody detects endogenous levels of RB1 only when phosphorylated at S780

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for RB1 [p Ser780] Antibody (24GB3950)

RB1 [p Ser780] Antibody (24GB3950)

Immunocytochemistry/ Immunofluorescence: RB1 [p Ser780] Antibody (24GB3950)[NBP3-50761] -

Immunocytochemical staining of HAP-1 cells with RB1 antibody (1:1,000). Nuclei were stained blue with DAPI; Phospho-retinoblastoma (S780) was stained magenta with Alexa Fluor(R) 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar, 20 um.
RB1 [p Ser780] Antibody (24GB3950)

Flow Cytometry: RB1 [p Ser780] Antibody (24GB3950)[NBP3-50761] -

Flow cytometric analysis of RB1expression in HAP-1 cells using RB1 antibody (1:2,000). Green, isotype control; red, Phospho-Retinoblastoma (S780).
RB1 [p Ser780] Antibody (24GB3950)

Western Blot: RB1 [p Ser780] Antibody (24GB3950)[NBP3-50761] -

Western blotting analysis using RB1 (S780) antibody (1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (1:20,000) respectively. Image was developed using FeQ(TM) ECL Substrate Kit.

Applications for RB1 [p Ser780] Antibody (24GB3950)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: RB1

Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of ts function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.

Long Name

Retinoblastoma-associated protein

Alternate Names

OSRC, p105-Rb, pp110

Gene Symbol

RB1

Additional RB1 Products

Product Documents for RB1 [p Ser780] Antibody (24GB3950)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for RB1 [p Ser780] Antibody (24GB3950)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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