PRMT5 Antibody (24GB845)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-51460

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NBP3-51460-100ul
NBP3-51460-20ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Knockdown Validated

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 24GB845

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all PRMT5 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human PRMT5 (Uniprot: O14744)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PRMT5 Antibody (24GB845)

PRMT5 Antibody (24GB845)

Immunocytochemistry/ Immunofluorescence: PRMT5 Antibody (24GB845)[NBP3-51460] -

Immunocytochemical staining of Hela cells with PRMT5 antibody (1:1,000). Nuclei were stained blue with DAPI; Protein arginine methyltransferase 5 was stained magenta with Alexa Fluor(R) 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 um.
PRMT5 Antibody (24GB845)

Flow Cytometry: PRMT5 Antibody (24GB845)[NBP3-51460] -

Flow cytometric analysis of PRMT5expression in HeLa cells using PRMT5 antibody (1:2,000). Green, isotype control; red, Protein arginine methyltransferase 5.

Applications for PRMT5 Antibody (24GB845)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Knockdown Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: PRMT5

Arginine methylation is an irreversible post translational modification linked to protein activity. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These proteins include nuclear proteins (Histone 2A, 3, 4), IL enhancer binding factor, nuclear factors (NF45, 90, ILF3, Nucleolin, STAT1, Poly(A) binding protein II), cell cycle proteins (phosphoprotein phosphatase 2A), signal transduction proteins (FGF2, Fibrillarin, FN, INFAR1, Jak, MBP, Src-adaptor Sam68), apoptosis proteins (FADD, ICE-like protease), and viral proteins (Hepatitis C NS3 RNA Helicase, HIV TAR). The mammalian PRMT family currently consists of 5 members that share two large domains of homology. Outside of these domains, epitopes were identified and antibodies against all five PRMT members have been developed. These antibodies can be utilized to explore arginine methylation and its regulatory functions.

Long Name

Protein arginine N-methyltransferase 5

Alternate Names

EC 2.1.1.320, HRMT1L5, IBP72, JBP1, SKB1, SKB1 homolog

Gene Symbol

PRMT5

Additional PRMT5 Products

Product Documents for PRMT5 Antibody (24GB845)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PRMT5 Antibody (24GB845)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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