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p53 [p Ser46] Antibody (GT1018) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-13598

Novus Biologicals, part of Bio-Techne
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NBP3-13598

Key Product Details

Validated by

Biological Validation

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # GT1018

Format

Azide and BSA Free

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Product Specifications

Immunogen

Carrier-protein conjugated synthetic peptide surrounding phospho Ser46 of human p53. The exact sequence is proprietary.

Modification

p Ser 46

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Description

Centrifuge briefly prior to opening.

Scientific Data Images for p53 [p Ser46] Antibody (GT1018) - Azide and BSA Free

Western Blot: p53 [p Ser46] Antibody (GT1018) [NBP3-13598] - Untreated (-) and treated (+) 293T whole cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with p53 (phospho Ser46) antibody [GT1018] (NBP3-13598) diluted at 1:1000. The HRP-conjugated anti-mouse IgG antibody (NBP2-19382) was used to detect the primary antibody.
Immunocytochemistry/Immunofluorescence: p53 [p Ser46] Antibody (GT1018) [NBP3-13598] - p53 (phospho Ser46) antibody [GT1018] detects p53 (phospho Ser46) protein at nucleus by immunofluorescent analysis. Sample: 293T cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: p53 (phospho Ser46) protein stained by p53 (phospho Ser46) antibody [GT1018] (NBP3-13598) diluted at 1:200. Blue: Hoechst 33342 staining. Scale bar = 10 um.
Immunohistochemistry-Paraffin: p53 [p Ser46] Antibody (GT1018) [NBP3-13598] - p53 (phospho Ser46) antibody [GT1018] detects p53 (phospho Ser46) protein at cytoplasm and nucleus by immunohistochemical analysis. Sample: Paraffin-embedded human pancreatic cancer. p53 (phospho Ser46) stained by p53 (phospho Ser46) antibody [GT1018] (NBP3-13598) diluted at 1:200. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Applications for p53 [p Ser46] Antibody (GT1018) - Azide and BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: p53

p53 is a stress-regulated transcription factor that was first identified as an SV40 large T antigen-binding protein. It plays a major role in the cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair, or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. Mutation of p53 is the most common genetic change so far identified in a number of major carcinomas. This antibody can be used for the specific detection of human p53 that is synthesized in the presence of p53 from other species.

Alternate Names

BCC7, LFS1, TP53, TRP53

Gene Symbol

TP53

Additional p53 Products

Product Documents for p53 [p Ser46] Antibody (GT1018) - Azide and BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for p53 [p Ser46] Antibody (GT1018) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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