p53: Antibodies
p53 is well known for its key role as a tumor suppressor protein. It is 393 amino acids (aa) in length with a predicted molecular weight of 44 kDa. It belongs to the p53 family that also includes p63 and p73. Structurally, p53 is characterized by an N-terminal transactivation domain, central DNA-binding and oligomerization domains, and a C-terminal regulatory domain. It is thought to exist as a homotetramer, and it exhibits approximately 72% and 76% aa identity with its mouse and rat orthologs, respectively. Mutations in the p53 gene are one of the most frequent genomic events accompanying oncogenic transformation. p53 responds to signals such as DNA damage or cell stress primarily through its actions as a transcription factor. Among its gene targets are a range factors that promote DNA repair mechanisms or apoptosis including cell cycle regulatory proteins and members the Bcl-2 family. Because of its critical role in genomic homeostasis, p53 activities are tightly regulated by a network of protein-protein interactions, microRNAs, and a range of post-translational modifications, including phosphorylation, acetylation, methylation, and ubiquitination. A widely studied regulator is Murine Double Minute 2 (MDM2). MDM2 is known to suppress p53 activity through direct binding or through its actions as a Ubiquitin ligase (E3) that catalyzes p53 ubiquitination and proteasome-mediated degradation.
30 results for "p53 Primary Antibodies" in Products
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p53: Antibodies
p53 is well known for its key role as a tumor suppressor protein. It is 393 amino acids (aa) in length with a predicted molecular weight of 44 kDa. It belongs to the p53 family that also includes p63 and p73. Structurally, p53 is characterized by an N-terminal transactivation domain, central DNA-binding and oligomerization domains, and a C-terminal regulatory domain. It is thought to exist as a homotetramer, and it exhibits approximately 72% and 76% aa identity with its mouse and rat orthologs, respectively. Mutations in the p53 gene are one of the most frequent genomic events accompanying oncogenic transformation. p53 responds to signals such as DNA damage or cell stress primarily through its actions as a transcription factor. Among its gene targets are a range factors that promote DNA repair mechanisms or apoptosis including cell cycle regulatory proteins and members the Bcl-2 family. Because of its critical role in genomic homeostasis, p53 activities are tightly regulated by a network of protein-protein interactions, microRNAs, and a range of post-translational modifications, including phosphorylation, acetylation, methylation, and ubiquitination. A widely studied regulator is Murine Double Minute 2 (MDM2). MDM2 is known to suppress p53 activity through direct binding or through its actions as a Ubiquitin ligase (E3) that catalyzes p53 ubiquitination and proteasome-mediated degradation.
30 results for "p53 Primary Antibodies" in Products
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Chromatin Immunoprecipitation, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Knockout Validated, Simple Western, Western Blot |
Clonality : | Polyclonal |
Host : | Rabbit IgG |
Applications : | Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #184727 |
Applications : | CyTOF-ready, Flow Cytometry |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #1022G |
Applications : | Western Blot |
Clonality : | Polyclonal |
Host : | Rabbit IgG |
Applications : | Immunohistochemistry, Simple Western, Western Blot |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2589A |
Applications : | Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #184721 |
Applications : | Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #261366 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #184727 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #261366 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2b Clone #197643 |
Applications : | Immunoprecipitation |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #261366 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #261366 |
Applications : | CyTOF-ready, Flow Cytometry, Immunocytochemistry/Immunofluorescence |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #184727 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2185A |
Applications : | Immunocytochemistry/Immunofluorescence, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #261366 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #184727 |
Applications : | Flow Cytometry |
Clonality : | Polyclonal |
Host : | Rabbit IgG |
Applications : | Simple Western, Western Blot |
Clonality : | Polyclonal |
Host : | Rabbit IgG |
Applications : | Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Immunoprecipitation |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #184727 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #184727 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #184727 |
Applications : | Flow Cytometry |