p130Cas/BCAR1 [p Tyr410] Antibody (23GB3870)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-51234

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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Flow Cytometry, Knockdown Validated

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 23GB3870

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all p130Cas Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human Phospho-p130Cas/BCAR1 (Y410) (Uniprot: P56945)

Modification

p Tyr410

Specificity

This antibody detects endogenous levels of p130Cas/BCAR1 only when phosphorylated at Y410

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for p130Cas/BCAR1 [p Tyr410] Antibody (23GB3870)

p130Cas/BCAR1 [p Tyr410] Antibody (23GB3870)

Flow Cytometry: p130Cas/BCAR1 [p Tyr410] Antibody (23GB3870)[NBP3-51234] -

Flow cytometric analysis of p130Cas/BCAR1expression in C2C12 cells using p130Cas/BCAR1 antibody (1:2,000). Green, isotype control; red, Phospho-BCAR1 (Y410).
p130Cas/BCAR1 [p Tyr410] Antibody (23GB3870)

Western Blot: p130Cas/BCAR1 [p Tyr410] Antibody (23GB3870)[NBP3-51234] -

Western blotting analysis using p130Cas/BCAR1 (Y410) antibody (1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (1:20,000) respectively. Image was developed using FeQ(TM) ECL Substrate Kit.

Applications for p130Cas/BCAR1 [p Tyr410] Antibody (23GB3870)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Knockdown Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: p130Cas

BCAR1/p130CAS functions as a scaffolding protein for components of various kinase signaling pathways. It is involved in integrin signaling for cell motility as well as netrin signaling for the guidance of commissural axons. Overexpression of BCAR1/p130CAS has been shown to confer antiestrogen resistance in breast cancer cells. Alternate names for BCAR1/p130CAS include breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, CAS scaffolding protein family member 1, CAS, and CRKAS.

Long Name

Breast Cancer Anti-estrogen Resistance 1

Alternate Names

BCAR1, CASS1, CRKAS

Gene Symbol

BCAR1

Additional p130Cas Products

Product Documents for p130Cas/BCAR1 [p Tyr410] Antibody (23GB3870)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for p130Cas/BCAR1 [p Tyr410] Antibody (23GB3870)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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