Nogo-A Antibody [DyLight 405]
Novus Biologicals, part of Bio-Techne | Catalog # AF3515E
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Western Blot, Immunocytochemistry
Label
DyLight 405 (Excitation = 400 nm, Emission = 420 nm)
Antibody Source
Polyclonal Sheep IgG
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human Nogo-A
Val566-Phe748
Accession # Q9NQC3
Val566-Phe748
Accession # Q9NQC3
Specificity
Detects human Nogo-A in direct ELISAs and Western blots. In direct ELISAs, approximately 5% cross-reactivity with recombinant rat Nogo-A (aa 543-725) and recombinant human Nogo-B is observed..
Clonality
Polyclonal
Host
Sheep
Isotype
IgG
Applications for Nogo-A Antibody [DyLight 405]
Application
Recommended Usage
Immunocytochemistry
Optimal dilutions of this antibody should be experimentally determined.
Western Blot
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Antigen Affinity-purified
Formulation
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: Nogo-A
Nogo-A, also known as Reticulon 4 (RTN4) is a transmembrane protein that is mainly expressed in oligodendrocytes of the central nervous system but is also reported in fibroblasts, dorsal root ganglion neurons, macrophages, and myoblasts. Binding of the Nogo66 region to the Nogo Receptor/p75 complex on axons induces growth cone collapse and blocks neurite outgrowth. Nogo-A interactions with the Nogo-B receptor (NgBR/NUS1) can regulate vascular remodeling, inhibit neuronal differentiation, and promote glial formation from neural progenitors.
Long Name
Reticulon 4A
Alternate Names
NI220, NogoA, RTN4, RTN4A
Gene Symbol
RTN4
Additional Nogo-A Products
Product Documents for Nogo-A Antibody [DyLight 405]
Product Specific Notices for Nogo-A Antibody [DyLight 405]
DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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