NGFRAP1/BEX3/NADE Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-77149

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NBP1-77149SS
NBP1-77149
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Predicted:

Bovine (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, ELISA

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all NGFRAP1/BEX3 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a peptide corresponding to 14 amino acids near the middle of human NADE. The immunogen is located within the last 50 amino acids of NADE.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for NGFRAP1/BEX3/NADE Antibody - BSA Free

Western Blot: NGFRAP1/BEX3/NADE AntibodyBSA Free [NBP1-77149]

Western Blot: NGFRAP1/BEX3/NADE AntibodyBSA Free [NBP1-77149]

Western Blot: NGFRAP1/BEX3/NADE Antibody [NBP1-77149] - Human brain cell lysates with NADE antibody at 1 u/mL in the presence (A) or absence (B) of blocking peptide.
NGFRAP1/BEX3/NADE Antibody - BSA Free

Immunohistochemistry: NGFRAP1/BEX3/NADE Antibody - BSA Free [NBP1-77149] -

Immunohistochemistry: NGFRAP1/BEX3/NADE Antibody - BSA Free [NBP1-77149] - Immunohistochemistry of NGFRAP1/BEX3/NADE in human brain tissue with NGFRAP1/BEX3/NADE antibody at 2 u/mL.

Applications for NGFRAP1/BEX3/NADE Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunohistochemistry

2 ug/ml

Immunohistochemistry-Paraffin

2 ug/ml

Western Blot

1 ug/ml
Application Notes
Despite its predicted molecular weight, NGFRAP1/BEX3/NADE migrates at ~23 kDa in SDS-PAGE.

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: NGFRAP1/BEX3

The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR. Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed. Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells, NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage.

Long Name

Nerve Growth Factor Receptor Associated Protein 1

Alternate Names

BEX3, HGR74, NADE

Gene Symbol

BEX3

UniProt

NP_996798 (Human)

Additional NGFRAP1/BEX3 Products

Product Documents for NGFRAP1/BEX3/NADE Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for NGFRAP1/BEX3/NADE Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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