Neuregulin-3/NRG3 Antibody (24GB3810)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-50744

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NBP3-50744-100ul
NBP3-50744-20ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 24GB3810

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Neuregulin-3/NRG3 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human Neuregulin-3/NRG3 (Uniprot: P56975)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Neuregulin-3/NRG3 Antibody (24GB3810)

Neuregulin-3/NRG3 Antibody (24GB3810)

Immunocytochemistry/ Immunofluorescence: Neuregulin-3/NRG3 Antibody (24GB3810)[NBP3-50744] -

Immunocytochemical staining of C2C12 cells with Neuregulin-3/NRG3 antibody (1:1,000). Nuclei were stained blue with DAPI; Neuregulin-3/NRG3 was stained magenta with Alexa Fluor(R) 647. Images were taken using leica stellaris 5. Protein abundance based on laser intensity and smart gain: Medium. Scale bar, 20 um
Neuregulin-3/NRG3 Antibody (24GB3810)

Flow Cytometry: Neuregulin-3/NRG3 Antibody (24GB3810)[NBP3-50744] -

Flow cytometric analysis of Neuregulin-3/NRG3expression in C2C12 cells using Neuregulin-3/NRG3 antibody (1:2,000). Green, isotype control; red, Neuregulin 3.
Neuregulin-3/NRG3 Antibody (24GB3810)

Western Blot: Neuregulin-3/NRG3 Antibody (24GB3810)[NBP3-50744] -

Western blotting analysis using Neuregulin-3/NRG3 antibody (1:5,000) and HRP-conjugated goat anti-rabbit secondary antibody (1:20,000) respectively. Image was developed using FeQ(TM) ECL Substrate Kit.

Applications for Neuregulin-3/NRG3 Antibody (24GB3810)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Neuregulin-3/NRG3

NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.

Alternate Names

Neuregulin3, NRG3

Gene Symbol

NRG3

Additional Neuregulin-3/NRG3 Products

Product Documents for Neuregulin-3/NRG3 Antibody (24GB3810)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Neuregulin-3/NRG3 Antibody (24GB3810)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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