Mouse T-bet/TBX21 Alexa Fluor™ Plus 488-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB11627AFP488

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FAB11627AFP488-100UG
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Key Product Details

Species Reactivity

Mouse

Applications

Immunohistochemistry, Western Blot

Label

Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)

Antibody Source

Monoclonal Rat IgG2B Clone # 1087415

View all T-bet/TBX21 Antibodies »

Product Specifications

Immunogen

Synthetic Peptide

Specificity

Detects a synthetic peptide specific for mouse T-bet around amino acid 20 in Direct ELISA.

Clonality

Monoclonal

Host

Rat

Isotype

IgG2B

Applications

Application
Recommended Usage

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: T-bet/TBX21

T-box transcription factor TBX21, also known as T-bet, is a 58kDa T-box gene which encodes transcription factors involved in the regulation of developmental processes. TBX21 is a Th1 cell-specific transcription that controls the expression of interferon-gamma. TBX21 also has an important role in many cells of the adaptive and innate immune system and is also expressed in dendritic cells, natural killer cells, natural killer T cells and innate lymphoid cells. T-bet contributes to the maintenance of mucosal homeostasis and mucosal immune response. Mice lacking adaptive immune cells and T-bet developed disease similar to human ulcerative colitis.  

References

  1. Lazarevic V, Glimcher LH, Lord GM. T-bet: a bridge between innate and adaptive immunity. Nat Rev Immunol. 2013 Nov;13(11):777-89. doi: 10.1038/nri3536. Epub 2013 Oct 11. PMID: 24113868; PMCID: PMC6290922. 
  2. Mohamed R, Lord GM. T-bet as a key regulator of mucosal immunity. Immunology. 2016 Apr;147(4):367-76. doi: 10.1111/imm.12575. Epub 2016 Feb 23. PMID: 26726991; PMCID: PMC4799884.

Long Name

T-box transcription factor TBX21

Alternate Names

T-PET, Tbet, TBLYM, TBX21

Entrez Gene IDs

30009 (Human); 57765 (Mouse); 303496 (Rat)

Gene Symbol

TBX21

UniProt

Q9JKD8 (Rabbit)

Additional T-bet/TBX21 Products

Product Documents

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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