Detects mouse Complement Component C1rLP in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 40% cross‑reactivity with recombinant human (rh) C1rLP is observed and less than 1% cross‑reactivity with rhC1R and rhC1S is observed.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Mouse Complement Component C1rLP Antibody

Application

Recommended Usage

Immunoprecipitation

25 µg/mL
Sample: Conditioned cell culture medium spiked with Recombinant Mouse Complement Component C1rLP, see our available Western blot detection antibodies

Western Blot

0.1 µg/mL
Sample: Recombinant Mouse Complement Component C1rLP

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Complement Component C1rLP

Mouse C1rLP, also CLSPa, is a 55 kDa, secreted, atypical glycoprotein member of the AGY group of servine proteases. It has protease activity for pro-haptoglobin, but accomplishes cleavage without a typical Asp in the catalytic site. In addition, it is proposed to block unwanted complement-mediated proteolysis. Mature C1rLP is 443 amino acids (aa) in length. It contains one CUB domain (aa 43‑165), a truncated CCP2 region (aa 167‑223) and a serine protease domain (aa 239‑482). There is a potential short form that utilizes an alternate start site at Met 27. Over aa 44‑456, mouse C1rLP is 78% and 90% aa identical to human and rat C1rLP, respectively.

Long Name

Complement C1r Subcomponent-like Protein

Alternate Names

C1RL, C1RL1, CLSPa

Entrez Gene IDs

51279 (Human); 232371 (Mouse)

Gene Symbol

C1RL

UniProt

AAP41417

Additional Complement Component C1rLP Products

Product Documents for Mouse Complement Component C1rLP Antibody

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for Mouse Complement Component C1rLP Antibody

For research use only

Citations
Reviews

Mouse Complement Component C1rLP Antibody

R&D Systems, part of Bio-Techne | Catalog # AF3990

Key Product Details

Species Reactivity

Validated:

Cited:

Applications