Detects mouse CD11c in direct ELISAs and Western blots. In direct ELISAs, 50%‑100% cross‑reactivity with recombinant human (rh) Integrin alphaX beta2 and recombinant mouse (rm) Integrin alphaL is observed, 10%‑25% cross‑reactivity with rhIntegrin CD11c, rhIntegrin alphaD beta2, and rhIntegrin alphaL beta2 is observed and no cross-reactivity with rhIntegrin alphaM or rhIntegrin beta2 is observed.

Clonality

Monoclonal

Host

Rat

Isotype

IgG_2B

Applications for Mouse CD11c Alexa Fluor™ Plus 488-conjugated Antibody

Application

Recommended Usage

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Background: CD11c

CD11c, also known as the Integrin alphaX subunit, is a 150 kDa type I transmembrane protein that noncovalently heterodimerizes with the beta2 subunit (CD18) to form alphaX/ beta2, also known as p150/p95 and complement receptor type 4 (CR4). Integrin alphaX beta2 is expressed on macrophages, dendritic cells, hairy cell leukemias and some other leukocyte subsets. The 1097 aa mouse CD11c extracellular domain shares 71% and 87% amino acid (aa) identity with human and rat CD11c, respectively. One potential alphaX isoform is truncated at aa 828. Some adhesion partners of alphaX beta2 are shared with alphaM beta2/CD11b/CD18 (Complement iC3b, ICAMs, vWF and Fibrinogen) while others (Osteopontin, Thy-1, Plasminogen, Heparin) are unique. Unlike alphaM beta2, it is not constitutively active. alphaX beta2 adhesion mediates proliferation, degranulation, chemotactic migration, and phagocytosis of complement-opsonized particles.

Alternate Names

CD11c, Integrin alpha X, ITGAX, p150,95 alpha

Entrez Gene IDs

3687 (Human); 16411 (Mouse); 64350 (Rat)

Gene Symbol

ITGAX

UniProt

Q9QXH4

Additional CD11c Products

Product Documents

Product Datasheets

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COA

SDS

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Product Specific Notices for Mouse CD11c Alexa Fluor™ Plus 488-conjugated Antibody

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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Mouse CD11c Alexa Fluor™ Plus 488-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB6950AFP488

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Species Reactivity

Applications

Label

Antibody Source

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Product Specifications

Specificity