Mouse CD11b/Integrin alpha M Alexa Fluor® 405-conjugated Antibody

Name: Mouse CD11b/Integrin alpha M Alexa Fluor® 405-conjugated Antibody
Brand: R&D Systems
SKU: FAB11242V

R&D Systems, part of Bio-Techne | Catalog # FAB11242V

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Product Datasheet / COA

Recombinant Monoclonal Antibody.

Key Product Details

Species Reactivity:	Mouse
Immunogen:	MouseCD11b/Integrin alpha M synthetic peptide Accession # P11215
Applications:	Western Blot
Label:	Alexa Fluor 405 (Excitation=405 nm, Emission=421 nm)
Specificity:	Detects mouse CD11b/Integrin alpha M in direct ELISAs.

View Full Technical Details for Mouse CD11b/Integrin alpha M Alexa Fluor® 405-conjugated Antibody

Technical Data
Citations / Reviews

Applications

	Recommended Concentration	Sample
Western Blot	Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application.

Formulation, Preparation and Storage

Purification	Protein A or G purified
Formulation	Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

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Background: CD11b/Integrin alpha M

The Integrin alpha M subunit (CD11b), associates with the Integrin beta 2 subunit (CD18) to form the non-covalent heterodimeric Integrin CD11b/CD18, also known as Mac-1 and CR-3. Upon activation, CD11b/CD18 is expressed on granulocytes, monocytes, a subset of NK cells and activated lymphocytes. Integrin CD11b/CD18 functions as a receptor for complement fragment iC3b, ICAM-1 (CD54), ICAM-2 (CD102) and fibrinogen to mediate phagocyte adhesion, migration and ingestion of complement-opsonized particles (1‑3).

Entrez Gene IDs

3684 (Human); 16409 (Mouse)

Alternate Names

CD11 antigen-like family member B, CD11b, CD11b antigen, CR-3 alpha chain, CR3A, CR3AMGC117044, Cell surface glycoprotein MAC-1 subunit alpha, Complement component 3 receptor 3 subunit, ITGAM, Integrin alpha M, Leukocyte adhesion receptor MO1, MAC-1, MAC1A, MO1A, Neutrophil adherence receptor, SLEB6, antigen CD11b (p170), integrin alpha-M, integrin, alpha M (complement component 3 receptor 3 subunit), macrophage antigen alpha polypeptide, neutrophil adherence receptor alpha-M subunit

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