MCCC1 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-81254

Novus Biologicals, part of Bio-Techne
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NBP1-81254
NBP1-81254-25ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Human, Mouse

Predicted:

Rat (90%). Backed by our 100% Guarantee.

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all MCCC1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: ITGTDLVEWQLRIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTNIDFLLNLSGHPEFEAGNVHTDFIPQHH

Reactivity Notes

Use in Mouse reported in scientific publication (PMID: 32561715).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for MCCC1 Antibody - BSA Free

Western Blot: MCCC1 Antibody [NBP1-81254]

Western Blot: MCCC1 Antibody [NBP1-81254]

Western Blot: MCCC1 Antibody [NBP1-81254] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp
Immunocytochemistry/ Immunofluorescence: MCCC1 Antibody [NBP1-81254]

Immunocytochemistry/ Immunofluorescence: MCCC1 Antibody [NBP1-81254]

Immunocytochemistry/Immunofluorescence: MCCC1 Antibody [NBP1-81254] - Immunofluorescent staining of human cell line U-2 OS shows localization to mitochondria. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: MCCC1 Antibody [NBP1-81254]

Immunohistochemistry-Paraffin: MCCC1 Antibody [NBP1-81254]

Immunohistochemistry-Paraffin: MCCC1 Antibody [NBP1-81254] - Staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells.

Applications for MCCC1 Antibody - BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

0.04-0.4 ug/ml
Application Notes
IHC-P Retrieval method: HIER pH6. ICC/IF Fixation/Permeabilization: PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MCCC1

MCCC1, also known as Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial, is a 725 amino acid protein that is 80 kDa, located in mitochondrion matrix, functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Studies on this protein have shown a relationship with the following diseases and disorders: 3 methylcrotonyl-coa carboxylase 1 deficiency, pseudomyxoma peritonei, mucinous cystadenocarcinoma, cystadenocarcinoma, 3-methylcrotonyl-coa carboxylase deficiency, carnitine deficiency, neisseria meningitides, Parkinson's disease, hypotonia, pneumonia, and tuberculosis. This protein has also been shown to have interactions with PPP2R2B, YWHAB, ACADM, AUH and ECHS1 in valine, leucine and isoleucine degradation, metabolic pathways, metabolism of amino acids and derivatives, and branched-chain amino acid catabolism pathways.

Alternate Names

3-methylcrotonyl-CoA carboxylase 1, DKFZp686B20267, EC 6.4.1, EC 6.4.1.4, MCCAFLJ25545, MCC-B, methylcrotonoyl-CoA carboxylase 1 (alpha), methylcrotonoyl-Coenzyme A carboxylase 1 (alpha), mitochondrial

Gene Symbol

MCCC1

Additional MCCC1 Products

Product Documents for MCCC1 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for MCCC1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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