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Kappa Light Chain Antibody (rL1C1) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-49431

Recombinant Monoclonal Antibody
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NBP3-49431

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Mouse IgG1 kappa Clone # rL1C1

Format

Azide and BSA Free

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Product Specifications

Immunogen

Human B-Lymphoma Cells (Uniprot: P01601)

Localization

Cell membrane, Secreted

Specificity

This antibody is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of kappa to lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin' lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Theoretical MW

22.5 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

Prepared in 10mM PBS WITHOUT BSA & azide at 1.0mg/ml. Also available with 0.05% BSA & 0.05% azide.

Antibody with azide - store at 2 to 8 C. Antibody without azide - store at -20 to -80 C. Antibody is stable for 24 months. Non-hazardous.

Scientific Data Images for Kappa Light Chain Antibody (rL1C1) - Azide and BSA Free

Kappa Light Chain Antibody (rL1C1) - Azide and BSA Free

Immunohistochemistry-Paraffin: Kappa Light Chain Antibody (rL1C1) - Azide and BSA Free [NBP3-49431] -

Formalin-fixed, paraffin-embedded human Tonsil stained with Kappa Light Chain Antibody (rL1C1) - Azide and BSA Free.
Kappa Light Chain Antibody (rL1C1) - Azide and BSA Free

Protein Array: Kappa Light Chain Antibody (rL1C1) - Azide and BSA Free [NBP3-49431] -

Analysis of Protein Array containing more than 19,000 full-length human proteins using Kappa Light Chain Antibody (rL1C1) - Azide and BSA Free.

Applications for Kappa Light Chain Antibody (rL1C1) - Azide and BSA Free

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10 mM PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -80C. Avoid freeze-thaw cycles.

Background: Kappa Light Chain

Kappa light chain antibody can be used for the identification of leukemias, plasmacytomas and certain non-Hodgkin's lymphomas. Kappa light chain contains one immunoglobulin-like domain. The EU sequence has the INV allotypic marker, Ala-45 and Val-83. The ROY sequence has the INV allotypic marker, Ala-45 and Leu-83.

Alternate Names

HCAK1, IGKCD, immunoglobulin kappa constant, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809

Gene Symbol

IGKC

Additional Kappa Light Chain Products

Product Documents for Kappa Light Chain Antibody (rL1C1) - Azide and BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Kappa Light Chain Antibody (rL1C1) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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