Key Product Details

Species Reactivity

Human

Applications

Label

Janelia Fluor 549

Antibody Source

Monoclonal Mouse IgG1 Clone # 614115

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all IRS1 Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human IRS1
Ala801-Ala1020 (predicted)
Accession # P35568

Specificity

Detects human IRS1 in direct ELISAs. In direct ELISAs, 100% cross-reactivity with recombinant mouse (rm) IRS1 (aa 898-1066) and no cross-reactivity with rmIRS1 (aa 13-113), rmIRS3, or recombinant human IRS2 is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: IRS1

Insulin receptor substrates (IRS), the major intracellular substrates of the insulin receptor (IR), are adaptor proteins that transduce signals from the IR to downstream effectors that are important for the biological effect of insulin (1-2). After insulin stimulation, IRS proteins are rapidly phosphorylated on multiple tyrosine residues. Once phosphorylated, IRS proteins bind and activate Grb-2, SHP2 and the PI3-K p85 subunit (2-3). IRS-1 functions as one of the key regulators of IR and the insulin-like growth factor-1 receptor. Disruption of IRS-1 causes growth retardation and insulin resistance associated with hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation (4-5)

Long Name

Insulin Receptor Substrate 1

Alternate Names

HIRS-1, insulin receptor substrate 1, IRS-1

Gene Symbol

IRS1

Additional IRS1 Products

Product Documents for IRS1 Antibody (614115) [Janelia Fluor® 549]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for IRS1 Antibody (614115) [Janelia Fluor® 549]



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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