Integrin alpha V beta 6 Antibody (Av beta6 62ow.17) - BSA Free
Novus Biologicals, part of Bio-Techne | Catalog # NBP2-50450
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human, Mouse (Negative)
Applications
Immunohistochemistry, Western Blot
Label
Unconjugated
Antibody Source
Monoclonal Rat IgG1 Clone # Av beta6 62ow.17
Format
BSA Free
Concentration
1 mg/ml
Product Specifications
Immunogen
Mouse fibroblasts retrovirally infected with cDNA to human beta6 (3T3 beta6.19). Cells expressed a mouse/human av beta6 chimera.
Specificity
Does not recognize mouse av beta 6.
Clonality
Monoclonal
Host
Rat
Isotype
IgG1
Applications for Integrin alpha V beta 6 Antibody (Av beta6 62ow.17) - BSA Free
Application
Recommended Usage
Immunohistochemistry
1:10 - 1:500
Western Blot
1:100 - 1:2000
Application Notes
Positive control(s): BT20 breast carcinoma, original immunogen.
Formulation, Preparation, and Storage
Purification
Protein G purified
Formulation
PBS
Format
BSA Free
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Background: Integrin alpha V beta 6
Integrin alpha V beta 6 (aVb6) is a heterodimeric adhesion protein that is exclusively expressed on subsets of epithelial cells, especially during development, after injury or inflammation, or on many carcinomas. Active aVb6 binds to the extracellular matrix proteins Fibronectin and Tenascin C as well as the TGF-beta latency-associated peptide (LAP). It cooperates with LTBP-1, Fibronectin, and PAR-1 to activate TGF-beta 1 or TGF-beta 3 from large latent complexes. aVb6 also plays a role in Treg development, tumor progression, and virus cellular entry.
Alternate Names
CD51, integrin subunit alpha V, ITGAV, MSK8, VNRA, VTNR
Gene Symbol
ITGAV
Additional Integrin alpha V beta 6 Products
Product Documents for Integrin alpha V beta 6 Antibody (Av beta6 62ow.17) - BSA Free
Product Specific Notices for Integrin alpha V beta 6 Antibody (Av beta6 62ow.17) - BSA Free
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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