Integrin alpha 2b beta 3 Antibody (10E5) [HRP]
Novus Biologicals, part of Bio-Techne | Catalog # NBP2-81080H
Recombinant Monoclonal Antibody
Conjugate
Catalog #
Forumulation
Catalog #
Key Product Details
Species Reactivity
Human
Applications
ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot
Label
HRP
Antibody Source
Recombinant Monoclonal Rabbit IgG Kappa Clone # 10E5
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
Human blood platelets.
Specificity
The antibody binds to Integrin alpha 2b beta 3 with an affinity (Kd) of 16.2+-6 nM. The antibody completely inhibits platelet aggregation at 7.8 ug/ml.
Clonality
Monoclonal
Host
Rabbit
Isotype
IgG Kappa
Applications for Integrin alpha 2b beta 3 Antibody (10E5) [HRP]
Application
Recommended Usage
ELISA
Optimal dilutions of this antibody should be experimentally determined.
Immunocytochemistry/ Immunofluorescence
Optimal dilutions of this antibody should be experimentally determined.
Western Blot
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A purified
Formulation
PBS
Preservative
No Preservative
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: Integrin alpha 2b beta 3
Integrin alpha 2b beta 3, also known as GPIIbIIIa, is the most abundant Integrin expressed by megakaryocytes and platelets, both on the surface and within alpha granules. Deficiencies of alpha 2b beta 3 produce Glanzmann thrombasthenia, a potentially serious bleeding disorder. Active cell surface alpha 2b beta 3 adheres to Fibrinogen, mediating platelet/platelet interactions that initiate a cascade of platelet activation and aggregation, extracellular matrix adhesion, formation of thrombi, and clot retraction. It also binds matrix proteins that have an RGD motif, including Fibronectin, Plasminogen, Prothrombin, Thrombospondin, and Vitronectin.
Alternate Names
BDPLT16;BDPLT2;CD41;CD41B;GP2B;GPIIb;GT;GT1;GTA;HPA3;Integrin alpha-IIb;ITGA2B;PPP1R93
Gene Symbol
ITGA2B
Additional Integrin alpha 2b beta 3 Products
Product Documents for Integrin alpha 2b beta 3 Antibody (10E5) [HRP]
Product Specific Notices for Integrin alpha 2b beta 3 Antibody (10E5) [HRP]
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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