Integrin alpha 2 beta 1 Antibody [CoraFluor™ 1] - (Research Grade vatelizumab Biosimilar)
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-28512CL1
Recombinant Monoclonal Antibody
![Integrin alpha 2 beta 1 Antibody [CoraFluor™ 1] - (Research Grade vatelizumab Biosimilar)](https://resources.bio-techne.com/images/products/nbp3-28512cl1_human-integrin-alpha-2-beta-1-mab-vatelizumab-cl1-3112202514282621.png "Product Feature: CoraFluor Probes for TR-FRET")
Conjugate
Catalog #
Forumulation
Catalog #
Key Product Details
Species Reactivity
Human
Applications
ELISA, Flow Cytometry, Functional
Label
CoraFluor 1
Antibody Source
Recombinant Monoclonal Human IgG4 expressed in CHO
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
Integrin a2b1 (ITGA2 & ITGB1)
Clonality
Monoclonal
Host
Human
Isotype
IgG4
Description
The heavy chain type is huIgG4SP, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.
Also known as 'vatelizumab'.
IgG4SP is human IgG4 with S228P mutation.
Also known as 'vatelizumab'.
IgG4SP is human IgG4 with S228P mutation.
Scientific Data Images
Product Feature: CoraFluor Probes for TR-FRET
CoraFluor™ 1, amine reactive (Catalog:7920) and CoraFluor™ 2, amine reactive (Catalog # 7950) are terbium-based probes that have been developed for use as TR-FRET donors. They emit wavelengths compatible with commonly used fluorescent acceptor dyes such as BODIPY® (or BDY) and Janelia Fluor® dyes, FITC (Catalog # 5440), TMR and Cyanine 5 (Catalog # 5436). CoraFluor™ fluorescence is brighter and more stable in biological media than existing TR-FRET donors, leading to enhanced sensitivity and improved data generation. CoraFluor™ 1 exhibits excitation upon exposure to a 337 nm UV laser.Applications
Application
Recommended Usage
ELISA
Optimal dilutions of this antibody should be experimentally determined.
Flow Cytometry
Optimal dilutions of this antibody should be experimentally determined.
Functional
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A purified
Formulation
PBS
Preservative
No Preservative
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark. Do not freeze.
Background: Integrin alpha 2 beta 1
Integrin alpha 2 beta 1 (VLA-2) is one of twelve Integrin family adhesion receptors that share the beta 1 subunit. It is one of six very late antigens expressed on activated T cells. Divalent cations and intracellular (inside-out) signaling convert it to its most active, extended, and open conformation. alpha 2 beta 1 binds to Collagen types I, II, and III, Laminin, Decorin, E-Cadherin, and Collectin molecules such as C1q. Platelet a2b1, also called GPIa, cooperates with GPVI to coordinate platelet collagen binding and activation. Adhesion is enhanced by crosstalk with Syndecan-1 or HGF R/c-Met and antagonized by crosstalk with Integrin a1b1. a2b1 is additionally expressed on select hematopoietic and non-hematopoietic cells.
Alternate Names
alpha 2 integrin, alpha 2 subunit of VLA-2 receptor, BR, CD49 antigen-like family member B, CD49b, collagen receptor, glycoprotein Ia, GPIa, HPA-5, human platelet alloantigen 5, human platelet alloantigen system 5, integrin alpha-2, integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), platelet antigen Br, platelet glycoprotein GPIa, platelet membrane glycoprotein Ia, very late activation protein 2 receptor, alpha-2 subunit, very late activation receptor alpha-2 subunit, very late activation receptor subunit alpha-2, VLA-2, VLAA2
Additional Integrin alpha 2 beta 1 Products
Product Specific Notices
CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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