Human ICAM-4 PE-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # FAB8397P
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Flow Cytometry
Label
Phycoerythrin (Excitation = 488 nm, Emission = 565-605 nm)
Antibody Source
Monoclonal Mouse IgG2B Clone # 729632
Product Specifications
Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human ICAM-4
Ala23-Ala240
Accession # Q14773
Ala23-Ala240
Accession # Q14773
Specificity
Detects human ICAM-4 in direct ELISAs.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2B
Scientific Data Images for Human ICAM-4 PE-conjugated Antibody
Detection of ICAM‑4 in Human Red Blood Cells by Flow Cytometry.
Human red blood cells were stained with Mouse Anti-Human ICAM-4 PE-conjugated Monoclonal Antibody (Catalog # FAB8397P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins.Applications for Human ICAM-4 PE-conjugated Antibody
Application
Recommended Usage
Flow Cytometry
10 µL/106 cells
Sample: Human red blood cells
Sample: Human red blood cells
Spectra Viewer
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
Spectra Viewer
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: ICAM-4
ICAM-4 (Intercellular Adhesion Molecule 4), also known as Landsteiner-Wiener Glycoprotein and CD242, is a 42 kDa member of the ICAM family, Ig superfamily of proteins. It is expressed on erythrocytes and erythroblasts, and serves as a receptor for LFA-1, Mac-1, and CD11c/CD18, plus alpha4 beta1 and alpha-V containing integrins. ICAM-4 is suggested to bind to Mac-1 on macrophages, allowing for its phagocytosis in senescence. Mature human ICAM-4 is a 249 amino acid (aa) type I transmembrane glycoprotein. It possesses a 218 aa extracellular region (aa 23-240) that contains two C2-type Ig-like domains (aa 62-124 and 146-217), and a 10 aa C-terminal cytoplasmic tail. ICAM-4 may form 85 kDa homodimers. There are three potential isoform variants. One shows a five aa substitution for aa 233-271, a second contains a 15 aa substitution for aa 14-29, and a third possesses a 141 aa substitution for aa 132-271. Over aa 31-240, human ICAM-4 shares 71% aa identity with mouse ICAM-4.
Long Name
Intercellular Adhesion Molecule 4
Alternate Names
CD242, ICAM4
Gene Symbol
ICAM4
UniProt
Additional ICAM-4 Products
Product Documents for Human ICAM-4 PE-conjugated Antibody
Product Specific Notices for Human ICAM-4 PE-conjugated Antibody
For research use only
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