Human TMIGD2/CD28H PE-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB83162P

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FAB83162P-100
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Conjugate
Catalog #
Unconjugated
MAB83162
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Alexa Fluor 350
FAB83162U
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Alexa Fluor 405
FAB83162V
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Alexa Fluor 488
FAB83162G
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Alexa Fluor 532
FAB83162X
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Alexa Fluor 594
FAB83162T
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Alexa Fluor 647
FAB83162R
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Alexa Fluor 700
FAB83162N
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Alexa Fluor 750
FAB83162S
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Alexa Fluor Plus 405
FAB83162AFP405
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Alexa Fluor Plus 488
FAB83162AFP488
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Alexa Fluor Plus 555
FAB83162AFP555
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Alexa Fluor Plus 594
FAB83162AFP594
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Alexa Fluor Plus 647
FAB83162AFP647
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Alexa Fluor Plus 680
FAB83162AFP680
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Allophycocyanin
FAB83162A
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Allophycocyanin/Cy7
FAB83162APCCY7
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Biotin
FAB83162B
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CoraFluor 1
FAB83162CL1
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DyLight 350
FAB83162D
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DyLight 405
FAB83162E
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DyLight 488
FAB83162K
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DyLight 550
FAB83162L
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DyLight 594
FAB83162M
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DyLight 650
FAB83162W
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DyLight 680
FAB83162Y
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DyLight 755
FAB83162Z
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FITC
FAB83162F
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HRP
FAB83162H
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Janelia Fluor 525
FAB83162JF525
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Janelia Fluor 549
FAB83162I
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Janelia Fluor 646
FAB83162J
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Janelia Fluor 669
FAB83162JF669
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mFluor Violet 450 SE
FAB83162MFV450
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mFluor Violet 500 SE
FAB83162MFV500
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mFluor Violet 610 SE
FAB83162MFV610
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PE/Atto594
FAB83162PEATT594
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PE/Cy5.5
FAB83162PECY55
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PE/Cy7
FAB83162PECY7
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PerCP
FAB83162C
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

Phycoerythrin (Excitation = 488 nm, Emission = 565-605 nm)

Antibody Source

Monoclonal Mouse IgG2A Clone # 953743

View all TMIGD2/CD28H Antibodies »

Product Specifications

Immunogen

Human embryonic kidney cell line HEK-293-derived human TMIGD2/CD28H
Accession # Q96BF3

Specificity

Detects human TMIGD2/CD28H in direct ELISAs.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Scientific Data Images for Human TMIGD2/CD28H PE-conjugated Antibody

Detection of TMIGD2/CD28H antibody in HEK293 Human Cell Line Transfected with Human TMIGD2/CD28H and eGFP antibody by Flow Cytometry.

Detection of TMIGD2/CD28H in HEK293 Human Cell Line Transfected with Human TMIGD2/CD28H and eGFP by Flow Cytometry.

HEK293 human embryonic kidney cell line transfected with human TMIGD2/CD28H and eGFP was stained with and either (A) Mouse Anti-Human TMIGD2/CD28H PE-conjugated Monoclonal Antibody (Catalog # FAB83162P) or (B) Mouse IgG2A Isotype Control (Catalog # IC003P). View our protocol for Staining Membrane-associated Proteins.

Applications for Human TMIGD2/CD28H PE-conjugated Antibody

Application
Recommended Usage

Flow Cytometry

10 µL/106 cells
Sample: HEK293 Human Cell Line Transfected with Human TMIGD2/CD28H and eGFP

Spectra Viewer

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

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Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: TMIGD2/CD28H

CD28 homolog (CD28H), also called TMIG2 and IGPR-1, is a 55 kDa glycosylated transmembrane protein that shares approximately 10% amino acid (aa) sequence identity with CD28, CTLA-4, ICOS, and PD-1. CD28H is composed of a single extracellular immunoglobulin variable-like domain (IgV) (aa 23-109), a transmembrane domain (aa 151-171), and a long cytoplasmic domain (aa172-282). CD28H is constitutively expressed on naive T and NK cells. Similar to the interaction of B7 with CD28, the interaction of CD28H with B7-H7 activates the Akt-dependent signaling cascade and promotes the proliferation and activation of newly generated peripheral effector and memory T cells (1, 2). CD28H is additionally expressed in the skin and epithelium lining the lung, airway, mammary gland, and gastrointestinal tract (3). It regulates cellular morphology, focal adhesion contact formation, and cell migration (3, 4). CD28H also participates in angiogenesis in vitro (3). CD28H interacts with multiple cytoskeletal proteins including Actin, Paxillin, SPIN90, CACNB2, and BPAG1. Interactions between the cytoplasmic proline-rich domain of CD28H and SPIN90 modulate the activity of CD28H in both angiogenesis and cell adhesion (3, 5).

References

  1. Zhu, Y. et al. (2013) Nat. Commun. 4:2043.
  2. Parry, R.V. et al. (2003) J.Immunol. 171:166.
  3. Rahimi, N. et al. (2012) Mol. Biol. Cell. 23:1646.
  4. Huang, C. et al. (2003) Nature 424:219.
  5. Kaneko, T. et al. (2008) Front. Biosci. 13:4938.

Long Name

Transmembrane And Immunoglobulin Domain Containing 2

Alternate Names

CD28H, IGPR-1, IGPR1

Entrez Gene IDs

126259 (Human)

Gene Symbol

TMIGD2

UniProt

Q96BF3

Additional TMIGD2/CD28H Products

Product Documents for Human TMIGD2/CD28H PE-conjugated Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Human TMIGD2/CD28H PE-conjugated Antibody

For research use only

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