Human Survivin Alexa Fluor® 647-conjugated Antibody

Name: Human Survivin Alexa Fluor® 647-conjugated Antibody
Brand: R&D Systems
SKU: AF886R

R&D Systems, part of Bio-Techne | Catalog # AF886R

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Product Datasheet / COA

Key Product Details

Species Reactivity:	Human
Immunogen:	E. coli-derived recombinant human Survivin aa 1-142
Applications:	Immunohistochemistry, Western Blot
Label:	Alexa Fluor 647 (Excitation=650 nm, Emission=668 nm)
Specificity:	Detects human Survivin. This antibody also detects an unidentified ~51 kDa protein band.

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Technical Data
Citations / Reviews

Applications

	Recommended Concentration	Sample
Western Blot	Optimal dilution of this antibody should be experimentally determined.
Immunohistochemistry	Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application.

Formulation, Preparation and Storage

Purification	Antigen Affinity-purified
Formulation	Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

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Background: Survivin

Survivin also known as Apoptosis inhibitor survivin and Baculoviral IAP repeat-containing protein 5 (BIRC5) is an 18 kDa member of the inhibitor of apoptosis (IAP) gene family, which encodes negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple Baculovirus IAP repeat (BIR) domains, but this gene encodes seven isoforms with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Survivin is expressed in a cell cycle-dependent manner and associates with the mitotic apparatus.

Item	Value
Entrez Gene IDs	332 (Human)
Alternate Names	API4, Apoptosis inhibitor survivin, BIRC5, Baculoviral IAP Repeat-Containing Protein 5, EPR-1, IAP4, Survivin, apoptosis inhibitor 4, baculoviral IAP repeat-containing 5, survivin variant 3 alpha

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