Human Prostasin/Prss8 Biotinylated Antibody
R&D Systems, part of Bio-Techne | Catalog # BAF4599
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
Biotin
Antibody Source
Polyclonal Sheep IgG
Product Specifications
Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human Prostasin/Prss8
Ala33-Gly319
Accession # Q16651
Ala33-Gly319
Accession # Q16651
Specificity
Detects human Prostasin/Prss8 in Western blots. In Western blots, approximately 10% cross‑reactivity with recombinant mouse Prostasin is observed.
Clonality
Polyclonal
Host
Sheep
Isotype
IgG
Applications for Human Prostasin/Prss8 Biotinylated Antibody
Application
Recommended Usage
Western Blot
0.1 µg/mL
Sample: Recombinant Human Prostasin/Prss8 (Catalog # 4599-SE)
Sample: Recombinant Human Prostasin/Prss8 (Catalog # 4599-SE)
Formulation, Preparation, and Storage
Purification
Antigen Affinity-purified
Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Prostasin/Prss8
Prostasin, also known as channel activating protease 1, is a serine protease with trypsin-like substrate specificity (1, 2). The preproenzyme possesses a C-terminal membrane-spanning domain that can be proteolytically processed to generate a secreted form of the enzyme. The secreted form of Prostasin has been purified from seminal fluid (2). Prostasin is highly expressed in the prostate gland, and is expressed at lower levels in the lung, kidney, liver, salivary gland, and pancreas (3). The peptidase activity of Prostasin is involved in the regulation of epithelial sodium channels (4, 5).
References
- Vuagniaux, G. et al. (2000) J. Am. Soc. Nephrol. 11:828.
- Yu, J.X. et al. (1994) J. Biol. Chem. 269:18843.
- Yu, J.X. et al. (1995) J. Biol. Chem. 270:13483.
- Caldwell, R.A. et al. (2004) Am. J. Physiol. Cell Physiol. 286:C194.
- Tong, Z. et al. (2004) Am. J. Physiol. Lung Cell Mol. Physiol. 287:L928.
Alternate Names
Prss8
Gene Symbol
PRSS8
UniProt
Additional Prostasin/Prss8 Products
Product Documents for Human Prostasin/Prss8 Biotinylated Antibody
Product Specific Notices for Human Prostasin/Prss8 Biotinylated Antibody
For research use only
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