Human Presenilin-2 C-Terminal Fragment Biotinylated Antibody
R&D Systems, part of Bio-Techne | Catalog # BAF197
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Immunohistochemistry, Western Blot
Label
Biotin
Antibody Source
Polyclonal Goat IgG
Product Specifications
Immunogen
E. coli-derived recombinant human Presenilin‑2 C-Terminal Fragment
aa 322-388
aa 322-388
Specificity
Detects human Presenilin‑2 C-Terminal Fragment in Western blots. In Western blots, less than 1% cross‑reactivity with recombinant human (rh) Presenilin‑1 N-Terminal Fragment (aa 1‑80), rhPresenilin‑1 C‑Terminal Fragment (aa 298‑407), and rhPresenilin‑2 N‑Terminal Fragment (aa 1‑80) is observed.
Clonality
Polyclonal
Host
Goat
Isotype
IgG
Applications for Human Presenilin-2 C-Terminal Fragment Biotinylated Antibody
Application
Recommended Usage
Immunohistochemistry
5-15 µg/mL
Sample: Immersion fixed paraffin-embedded sections of human Alzheimer's disease brain subjected to Antigen Retrieval Reagent-Basic (Catalog # CTS013)
Sample: Immersion fixed paraffin-embedded sections of human Alzheimer's disease brain subjected to Antigen Retrieval Reagent-Basic (Catalog # CTS013)
Western Blot
0.1 µg/mL
Sample: Recombinant Human Presenilin-2 C-Terminal Fragment
Sample: Recombinant Human Presenilin-2 C-Terminal Fragment
Formulation, Preparation, and Storage
Purification
Antigen Affinity-purified
Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Presenilin-2
Presenilin-1 (PS-1) and Presenilin-2 (PS-2) are integral membrane proteins that contain multiple transmembrane domains. Both are predominantly located within the endoplasmic reticulum (ER) and early Golgi apparatus. They are primarily expressed in neurons and are ubiquitously expressed in the brain. PS-1 and PS-2 are proteolytically cleaved to generate an N-terminal fragment (NTF) and a C-terminal fragment (CTF). Mutations in the gene for Presenilin may play an important role in the pathology of Alzheimer's disease.
Additional Presenilin-2 Products
Product Documents for Human Presenilin-2 C-Terminal Fragment Biotinylated Antibody
Product Specific Notices for Human Presenilin-2 C-Terminal Fragment Biotinylated Antibody
For research use only
Loading...
Loading...
Loading...
Loading...
Loading...