Human Presenilin-2 C-Terminal Fragment Biotinylated Antibody
R&D Systems, part of Bio-Techne | Catalog # BAF197

Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Immunogen
aa 322-388
Specificity
Clonality
Host
Isotype
Applications for Human Presenilin-2 C-Terminal Fragment Biotinylated Antibody
Immunohistochemistry
Sample: Immersion fixed paraffin-embedded sections of human Alzheimer's disease brain subjected to Antigen Retrieval Reagent-Basic (Catalog # CTS013)
Western Blot
Sample: Recombinant Human Presenilin-2 C-Terminal Fragment
Formulation, Preparation, and Storage
Purification
Reconstitution
Formulation
Shipping
Stability & Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Presenilin-2
Presenilin-1 (PS-1) and Presenilin-2 (PS-2) are integral membrane proteins that contain multiple transmembrane domains. Both are predominantly located within the endoplasmic reticulum (ER) and early Golgi apparatus. They are primarily expressed in neurons and are ubiquitously expressed in the brain. PS-1 and PS-2 are proteolytically cleaved to generate an N-terminal fragment (NTF) and a C-terminal fragment (CTF). Mutations in the gene for Presenilin may play an important role in the pathology of Alzheimer's disease.
Additional Presenilin-2 Products
Product Documents for Human Presenilin-2 C-Terminal Fragment Biotinylated Antibody
Product Specific Notices for Human Presenilin-2 C-Terminal Fragment Biotinylated Antibody
For research use only